Sections
Treatment During Late Life: Introduction | Pharmacokinetics of Psychotropic Medications in the
Elderly | Pharmacodynamics of Psychotropic Medications in the
Elderly | Antidepressants in the Elderly | Antipsychotics in the Elderly | Conclusion | References
Excerpt
Adverse events caused by medication have been
estimated to be between the fourth and sixth leading cause of death
in the United States (Lazarou et al. 1998). The elderly
bear the greatest burden of medical illness and are subject to extensive
medication regimens; in consequence, they experience more adverse
drug events than do other segments of the population. In a large
study of ambulatory Medicare enrollees, 38% of adverse
drug events were serious, life-threatening, or fatal and 28% were
considered preventable (Gurwitz et al. 2005). Moreover,
psychotropics are among the most common medications associated with
preventable adverse drug events in elderly patients in long-term
care settings (Gurwitz et al. 2000).