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The analgesic effects of opium have been known to mankind for more than 5,000 years. However, their inherent risk of abuse soon became evident. Ever since, society has attempted to find a balance between licit and illicit use, therapeutic versus adverse effects, and medical needs and legal issues. Despite all the legal, administrative, and social interference, no other class of drugs has remained in use for as long as opioids. (Schug 2005)

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Table Reference Number
TABLE 66–1. Oral and transdermal opioid analgesic equivalence

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