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Dementias With Cortical and Subcortical Features

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FIGURE 8–9. T2 magnetic resonance image of vascular dementia, multi-infarct type, in a patient with diabetes mellitus and hypertension.The bilateral, symmetrical pattern of white matter lesions is characteristic of small-vessel arterial disease. Enlarged sulci are consistent with associated parenchymal loss.Source. Reprinted with permission from Yock DH: Imaging of CNS Disease: A CT and MRI Teaching File. St. Louis, MO, Mosby–Year Book, Inc., 1991.

FIGURE 8–10. Histopathology images: Lewy body variant of Alzheimer's disease.In this patient with dementia, the number of plaques and tangles in the neocortex was borderline for the diagnosis of Alzheimer's disease. A, The substantia nigra showed a moderate degree of nerve cell loss and small numbers of Lewy bodies. B, Ubiquitin immunohistochemistry revealed multiple Lewy bodies in nerve cells of the cingulate gyrus.Source. Reprinted from Davis RL, Robertson DM (eds): Textbook of Neuropathology, 3rd Edition. Baltimore, MD, Williams & Wilkins, 1997. Copyright 1997, Williams & Wilkins. Used with permission.

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