Sections
Definition and Description | Epidemiology | Pathophysiology | Assessment and Diagnosis | Treatment
Excerpt
Narcolepsy is a syndrome characterized by profound excessive
daytime sleepiness (EDS), which often occurs in association with
cataplexy, hypnagogic or hypnopompic hallucinations, sleep paralysis,
automatic behavior, and disrupted nocturnal sleep (American Academy of Sleep Medicine 2005). It is subdivided into two
types: narcolepsy with cataplexy and narcolepsy without cataplexy.
EDS is manifest as an increased propensity to fall asleep in relaxed
or sedentary situations or a struggle to avoid sleeping in these
situations. EDS may be so severe as to be irresistible, leading
to sleep in inappropriate or dangerous situations. Brief naps temporarily
relieve the sleepiness in many patients. EDS can lead to related
symptoms, including "automatic behavior" (behavior
that the individual does not recall), irritability, and poor memory,
concentration, and attention. The overall amount of sleep per 24
hours is not increased in narcolepsy. In fact, many patients report
fragmented nocturnal sleep, suggesting that the underlying disorder
is an inability to maintain any stable sleep–wake state
(Guilleminault and Fromherz 2005).