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Trazodone is an antidepressant that is associated with significant sedation. Currently, trazodone is not recommended as a first-line antidepressant because of an increased risk of orthostatic hypotension, arrhythmias, and priapism. However, trazodone may be useful in some patients with insomnia (although the use of trazodone specifically for insomnia is not approved by the FDA).

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