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Oral MAOIs are not currently used as first-line agents in the treatment of major depression, largely because newer antidepressants are generally safer and better tolerated. However, these medications remain excellent medications for patients who do not respond to the newer antidepressant drugs. Patients with atypical depression, characterized by oversleeping and overeating, show a preferential response to MAOI therapy (Quitkin et al. 1979). Recently, a patch containing the MAOI selegiline has become available, as discussed later in this section.

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Table Reference Number
TABLE 26–4. Monoamine oxidase inhibitor reversibility and selectivity
Table Reference Number
TABLE 26–5. Dietary and medication restrictions for patients taking nonselective monoamine oxidase inhibitors (MAOIs)

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