Mechanism of Action | Indications and Efficacy | Clinical Use | Contraindications and Pretreatment Medical Evaluation | Risks, Side Effects, and Their Management | Overdose and Toxicity | Drug Interactions
Lithium is a cation that inhibits several steps in phosphoinositide
metabolism, as well as many second and third messengers, including
G proteins and protein kinases (Bitran et al. 1995; Lenox et al. 1992; Manji et al. 1993, 1995, 1999). Recent
evidence suggests that lithium ultimately stimulates neurite growth,
regeneration, and neurogenesis, which is likely related to its therapeutic
effect (Coyle and Duman 2003; Kim et al. 2004).