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Many areas of the brain are involved in the production and mediation of aggressive behavior, and lesions at different levels of neuronal organization can elicit specific types of aggressive behaviors. Van der Naalt (2000) found that more lesions, mainly localized in the frontotemporal region, were found in those patients manifesting restlessness and agitation (81% vs. 39%). Frontal lesions have been found to be associated with aggressive behavior by some groups (Tateno et al. 2003) but not by others (Rao et al. 2009). Several anatomic areas of the brain are important in the production (or lack of suppression) of "irritative aggression," that is, feelings of irritability with occasional explosions. Table 14–3 summarizes the roles of key regions of the brain in mediating aggression. Many areas of the brain are involved in the production and mediation of aggressive behavior, and lesions at different levels of neuronal organization can elicit specific types of aggressive behaviors.

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Table Reference Number
Table 14–3. Neuropathology of aggression

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