Stimulant Drugs | New-Generation Stimulants | Nonstimulants
Stimulant drugs were the first class of compounds reported
as being effective in treating the behavioral disturbances that
are evident in children with ADHD (Table 4–1). Stimulants
are sympathomimetic drugs structurally similar to endogenous catecholamines.
The most commonly used compounds in this class are methylphenidate
(Ritalin), d-methylphenidate (Focalin), d-amphetamine
(Dexedrine), and a mixed amphetamine product (Adderall). These drugs
have been shown to enhance dopaminergic and noradrenergic neurotransmission
(Bymaster et al. 2002; Volkow et al. 2001).
Because the various stimulants have somewhat different mechanisms
of action, some patients may respond preferentially to one or another
agent (Greenhill et al. 1998).