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Acute-Phase Studies
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Figure 24–1. Course of depressive severity from baseline (M0) to month 8 (M8) among intent-to-treat primary care cohorts randomized to interpersonal psychotherapy (IPT), nortriptyline hydrochloride (NT), or usual care (UC).HAM-D = 17-item Hamilton Rating Scale for Depression (Hamilton 1960).Source. Reprinted from Schulberg HC, Block MR, Madonia M, et al.: "Treating Major Depression in Primary Care Practice: Eight-Month Clinical Outcomes." Archives of General Psychiatry 53:913–919, 1996. Copyright 1996. Used with permission.

Figure 24–2. Relationship of treatment specificity and delta ratio to time to recurrence.Note. High delta ratio/high focus, n = 13; low delta ratio/high focus, n = 8; high delta ratio/low focus, n = 13; and low delta ratio/low focus, n = 7.Source. Reprinted from Spanier C, Frank E, McEachran AB, et al.: "The Prophylaxis of Depressive Episodes in Recurrent Depression Following Discontinuation of Drug Therapy: Integrating Psychological and Biological Factors." Psychological Medicine 26:461–475, 1996. Copyright 1996. Used with permission.

Figure 24–3. Survival function of four treatment groups stratified by age at current major depressive episode.Note. Kaplan-Meier tests of survival function were significant for subjects ages 60–69 years (log rank = 25.9; df = 3; P = 0.001) and subjects 70 years or older (log rank = 9.05; df = 3; P = 0.03). Pairwise contrasts within each age stratum were not performed due to small sample sizes. IPT = interpersonal psychotherapy.Source. Reprinted from Reynolds CF III, Frank E, Perel JM, et al.: "Nortriptyline and Interpersonal Psychotherapy as Maintenance Therapies for Recurrent Major Depression: A Randomized Controlled Trial in Patients Older Than 59 Years." JAMA 281:39–45, 1999a. Copyright 1999. Used with permission.

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