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Combining Cognitive-Behavioral Therapy and Pharmacotherapy

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A recent multisite study of treatment for panic disorder provided the most systematic examination of the effects of combining CBT and medication to date (Barlow et al. 2000). Four treatment sites were used in this investigation: two with more commitment to CBT and two with more allegiance to pharmacotherapy. The RCT compared the acute and long-term effects of CBT alone, imipramine plus medical management, the combination of CBT plus imipramine, pill placebo plus medical management, and the combination of CBT and pill placebo. Individuals who were classified as responders to 11 sessions of acute treatment received 6 months of maintenance treatment (one session monthly of whichever treatment they received in the acute phase).

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