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Chapter 11. Depressive Disorders

Melvin McInnis, MD, F.R.C.Psych.; Michelle Riba, M.D., M.S.; John Greden, M.D.
DOI: 10.1176/appi.books.9781585625031.281772

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Excerpt

DSM-5 (American Psychiatric Association 2013) represents an important stage in the clinical classification of depressive disorders. and will evolve with emerging advances in neurobiology. The DSM-5 categories will continue as the “clinical currency” in medical practice; however, the deepening of understanding of the pathological processes and etiology in neuroscience is likely to reveal biological blurring of boundaries between the current categories. It is therefore critical that DSM-5 be adaptive and open to receive new information that has been vetted and independently replicated with confidence. As biological markers emerge from genetics, biochemistry, and cell biology, they will be studied on a large scale; markers that reflect biological mechanisms should be incorporated into classification systems and further studied, and the understanding of the biology of depression then refined. The process is iterative and informative. An emphasis on the refinement of knowledge, advancement, and development of research ideas and hypotheses to be sequentially tested in large patient populations will provide DSM-5 with fertile soil to evolve with emerging knowledge.

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DSM-5 depressive disorders

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