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Published Online: 1 March 2013

Disrupted Expected Value and Prediction Error Signaling in Youths With Disruptive Behavior Disorders During a Passive Avoidance Task

Stuart F. White, Ph.D., Kayla Pope, M.D., Stephen Sinclair, Ph.D., Katherine A. Fowler, Ph.D., Sarah J. Brislin, B.A., W. Craig Williams, B.S., Daniel S. Pine, M.D., and R. James R. Blair, Ph.D.Authors Info & Affiliations

Publication: American Journal of Psychiatry

Volume 170, Number 3

https://doi.org/10.1176/appi.ajp.2012.12060840

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Abstract

Objective

Youths with disruptive behavior disorders, including conduct disorder and oppositional defiant disorder, show major impairments in reinforcement-based decision making. However, the neural basis of these difficulties remains poorly understood. This partly reflects previous failures to differentiate responses during decision making and feedback processing and to take advantage of computational model-based functional MRI (fMRI).

Method

Participants were 38 community youths ages 10–18 (20 had disruptive behavior disorders, and 18 were healthy comparison youths). Model-based fMRI was used to assess the computational processes involved in decision making and feedback processing in the ventromedial prefrontal cortex, insula, and caudate.

Results

Youths with disruptive behavior disorders showed reduced use of expected value information within the ventromedial prefrontal cortex when choosing to respond and within the anterior insula when choosing not to respond. In addition, they showed reduced responsiveness to positive prediction errors and increased responsiveness to negative prediction errors within the caudate during feedback.

Conclusions

This study is the first to determine impairments in the use of expected value within the ventromedial prefrontal cortex and insula during choice and in prediction error-signaling within the caudate during feedback in youths with disruptive behavior disorders.

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Information & Authors

Information

Published In

Go to American Journal of Psychiatry

Go to American Journal of Psychiatry

American Journal of Psychiatry

Volume 170 • Number 3 • March 2013

Pages: 315 - 323

PubMed: 23450288

History

Received: 25 June 2012

Revision received: 3 September 2012

Accepted: 1 October 2012

Published online: 1 March 2013

Published in print: March 2013

Authors

Details

Stuart F. White, Ph.D.

From the National Institute of Mental Health, Bethesda, Md.; and Boys Town National Research Hospital, Omaha, Neb.

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Kayla Pope, M.D.

From the National Institute of Mental Health, Bethesda, Md.; and Boys Town National Research Hospital, Omaha, Neb.

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Stephen Sinclair, Ph.D.

From the National Institute of Mental Health, Bethesda, Md.; and Boys Town National Research Hospital, Omaha, Neb.

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Katherine A. Fowler, Ph.D.

From the National Institute of Mental Health, Bethesda, Md.; and Boys Town National Research Hospital, Omaha, Neb.

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Sarah J. Brislin, B.A.

From the National Institute of Mental Health, Bethesda, Md.; and Boys Town National Research Hospital, Omaha, Neb.

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W. Craig Williams, B.S.

From the National Institute of Mental Health, Bethesda, Md.; and Boys Town National Research Hospital, Omaha, Neb.

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Daniel S. Pine, M.D.

From the National Institute of Mental Health, Bethesda, Md.; and Boys Town National Research Hospital, Omaha, Neb.

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R. James R. Blair, Ph.D.

From the National Institute of Mental Health, Bethesda, Md.; and Boys Town National Research Hospital, Omaha, Neb.

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Notes

Address correspondence to Dr. White ([email protected]).

Funding Information

The authors report no financial relationships with commercial interests.

Supplementary Material

Supported by the Intramural Research Program of NIMH/NIH under grant 1-ZIA-MH002860-08.

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