Biochemical and Pharmacological Variations in Manic-Depressive Illness

CHRISTIAAN D. VAN DER VELDE and MALCOLM W. GORDONAuthors Info & Affiliations

Publication: American Journal of Psychiatry

Volume 129, Number 3

https://doi.org/10.1176/ajp.129.3.337

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Abstract

The response of 21 manic-depressives to imipramine was followed over a period of two years, during which both manic and depressed states were treated. Most patients responded differently to this treatment at different times. The variation in response is considered in the context of a hypothecated biochemical instability in the manic-depressive that is manifest in behavioral, pharmacological, and biochemical measures.

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Information & Authors

Information

Published In

American Journal of Psychiatry

Volume 129 • Number 3 • September 1972

Pages: 337 - 342

PubMed: 5053716

History

Published in print: September 1972

Published online: 1 April 2006

Authors

Details

CHRISTIAAN D. VAN DER VELDE

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MALCOLM W. GORDON

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Research Psychiatrist, Abraham Ribicoff Research Center, Norwich Hospital, Norwich, Conn. 06360

Director of the Abraham Ribicoff Research Center, Abraham Ribicoff Research Center, Norwich Hospital, Norwich, Conn. 06360

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Biochemical and Pharmacological Variations in Manic-Depressive Illness

Abstract

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