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Published Online: 1 June 2023

Alterations in Resting-State Interhemispheric Coordination With Refractory Auditory Verbal Hallucinations in Schizophrenia

Huichang Qian, M.Psy., Xiaozheng Liu, Ph.D., Zhongwei Guo, M.M., Guanjun Wang, M.B.B.S., Xiuhong Chen, M.B.B.S., M.Psy., and Jian Liu, M.B.B.S., M.Psy. [email protected]Authors Info & Affiliations
Publication: The Journal of Neuropsychiatry and Clinical Neurosciences
Volume 35, Number 4
https://doi.org/10.1176/appi.neuropsych.20220054
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Abstract

Objective:

The purpose of this study was to investigate resting-state interhemispheric functional connectivity in patients with schizophrenia and refractory auditory verbal hallucinations (RAVHs) by using voxel-mirrored homotopic connectivity (VMHC).

Methods:

Thirty-four patients with schizophrenia and RAVHs (RAVH group), 23 patients with schizophrenia but no auditory verbal hallucinations (non-AVH group), and 28 matched healthy volunteers (healthy control group) were recruited in China. VMHC analyses were used to identify brain areas with significant differences in functional connectivity among the three groups, and correlations between symptom scores and neurological measures were examined.

Results:

VMHC analyses showed aberrant bilateral connectivity between several homotopic brain regions: the RAVH and non-AVH groups showed differences in bilateral connectivity of the superior and middle temporal gyri, and the RAVH and healthy control groups showed differences in bilateral connectivity of the gyrus rectus, inferior frontal gyrus, and putamen. In addition, interhemispheric connectivity of the superior and middle temporal gyri correlated with patients’ positive symptom scores.

Conclusions:

These findings may help to elucidate the pathophysiological mechanisms underlying auditory verbal hallucinations. The results revealed interhemispheric functional dysconnectivity among patients with schizophrenia and suggest that the dysconnectivity of homotopic brain regions may play an important role in the development of auditory verbal hallucinations.

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Information & Authors

Information

Published In

Go to The Journal of Neuropsychiatry and Clinical Neurosciences
Go to The Journal of Neuropsychiatry and Clinical Neurosciences
The Journal of Neuropsychiatry and Clinical Neurosciences
Volume 35 • Number 4 • Fall 2023
Pages: 385 - 392
PubMed: 37259546

History

Received: 10 March 2022
Revision received: 3 September 2022
Revision received: 7 February 2023
Accepted: 1 March 2023
Published online: 1 June 2023
Published in print: Fall 2023

Keywords

  1. Auditory Verbal Hallucination
  2. Voxel-Mirrored Homotopic Connectivity
  3. Resting State Functional Connectivity
  4. Schizophrenia

Authors

Affiliations

Huichang Qian, M.Psy.
School of Mental Health and Psychological Sciences, Anhui Medical University, Hefei, China (Qian, J. Liu); Department of Radiology, Second Affiliated Hospital and Yuying Children’s Hospital, Wenzhou Medical University, Wenzhou, China (X. Liu); Department of Psychiatry, Tongde Hospital of Zhejiang Province, Hangzhou, China (Guo); and Departments of Radiology (Wang), Psychogeriatrics (Chen), and Science and Education (J. Liu), Hangzhou Seventh People’s Hospital, Hangzhou, China.
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Xiaozheng Liu, Ph.D.
School of Mental Health and Psychological Sciences, Anhui Medical University, Hefei, China (Qian, J. Liu); Department of Radiology, Second Affiliated Hospital and Yuying Children’s Hospital, Wenzhou Medical University, Wenzhou, China (X. Liu); Department of Psychiatry, Tongde Hospital of Zhejiang Province, Hangzhou, China (Guo); and Departments of Radiology (Wang), Psychogeriatrics (Chen), and Science and Education (J. Liu), Hangzhou Seventh People’s Hospital, Hangzhou, China.
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Zhongwei Guo, M.M.
School of Mental Health and Psychological Sciences, Anhui Medical University, Hefei, China (Qian, J. Liu); Department of Radiology, Second Affiliated Hospital and Yuying Children’s Hospital, Wenzhou Medical University, Wenzhou, China (X. Liu); Department of Psychiatry, Tongde Hospital of Zhejiang Province, Hangzhou, China (Guo); and Departments of Radiology (Wang), Psychogeriatrics (Chen), and Science and Education (J. Liu), Hangzhou Seventh People’s Hospital, Hangzhou, China.
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Guanjun Wang, M.B.B.S.
School of Mental Health and Psychological Sciences, Anhui Medical University, Hefei, China (Qian, J. Liu); Department of Radiology, Second Affiliated Hospital and Yuying Children’s Hospital, Wenzhou Medical University, Wenzhou, China (X. Liu); Department of Psychiatry, Tongde Hospital of Zhejiang Province, Hangzhou, China (Guo); and Departments of Radiology (Wang), Psychogeriatrics (Chen), and Science and Education (J. Liu), Hangzhou Seventh People’s Hospital, Hangzhou, China.
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Xiuhong Chen, M.B.B.S., M.Psy.
School of Mental Health and Psychological Sciences, Anhui Medical University, Hefei, China (Qian, J. Liu); Department of Radiology, Second Affiliated Hospital and Yuying Children’s Hospital, Wenzhou Medical University, Wenzhou, China (X. Liu); Department of Psychiatry, Tongde Hospital of Zhejiang Province, Hangzhou, China (Guo); and Departments of Radiology (Wang), Psychogeriatrics (Chen), and Science and Education (J. Liu), Hangzhou Seventh People’s Hospital, Hangzhou, China.
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Jian Liu, M.B.B.S., M.Psy. [email protected]
School of Mental Health and Psychological Sciences, Anhui Medical University, Hefei, China (Qian, J. Liu); Department of Radiology, Second Affiliated Hospital and Yuying Children’s Hospital, Wenzhou Medical University, Wenzhou, China (X. Liu); Department of Psychiatry, Tongde Hospital of Zhejiang Province, Hangzhou, China (Guo); and Departments of Radiology (Wang), Psychogeriatrics (Chen), and Science and Education (J. Liu), Hangzhou Seventh People’s Hospital, Hangzhou, China.
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Notes

Send correspondence to Dr. J. Liu ([email protected]).

Competing Interests

The authors report no financial relationships with commercial interests.

Funding Information

Mr. Qian and Dr. X. Liu share first authorship.
This work was supported by the Public Projects of the Department of Science and Technology of Zhejiang Province (grant 2013C33095).

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