Supplemental Material:

Table S1. Results of Linear Mixed-Effects Models Examining Predictors of Cognitive Change (Global Z-Scores) including FDG-PET and any NPS; Abbreviations: NPS, any neuropsychiatric symptom as measured by Neuropsychiatric Inventory Questionnaire, FDG, brain glucose metabolism as measured by FDG-PET

Estimate	Lower CI	Upper CI	P value
Time	-0.06117	-0.06847	-0.05387	<.0001
Time * z-score FDG	-0.03961	-0.04686	-0.03236	<.0001
Time * any NPS	-0.02750	-0.04341	-0.01158	0.0007
Time*z-score FDG* any NPS	0.002174	-0.01508	0.01943	0.8049