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Abstract

A group of eight patients with severe depression lasting 6 years or longer were treated with anterior capsulotomy and followed prospectively. Stereotactic surgery was used to produce radiofrequency lesions in the anterior limbs of both internal capsules. For all patients, there are follow-up data for at least 24 months. At 24-to-36 months postoperatively, four patients were either not-depressed or mildly depressed; one was mildly-to-moderately depressed; one was moderately-to-severely depressed; and only one remained severely depressed. One patient developed a progressive vascular dementia with parkinsonism caused by autopsy-proven arteriolosclerosis.

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Published In

Go to The Journal of Neuropsychiatry and Clinical Neurosciences
Go to The Journal of Neuropsychiatry and Clinical Neurosciences
The Journal of Neuropsychiatry and Clinical Neurosciences
Pages: 176 - 182
PubMed: 22772665

History

Received: 15 August 2011
Revision received: 17 December 2011
Accepted: 26 December 2011
Published online: 1 April 2012
Published in print: Spring 2012

Authors

Details

Trevor A. Hurwitz, MBChB, MRCP, FRCPC
From the Department of Psychiatry (TAH, JA, CG, RH), Department of Surgery, Division of Neurosurgery (CH), Department of Medicine, Division of Neurology (JM, NB), University of British Columbia, Vancouver, British Columbia, Canada; Forstrom-Jackson, Vancouver, British Columbia, Canada (PT).
Christopher R. Honey, M.D., D.Phil., FRCSC
From the Department of Psychiatry (TAH, JA, CG, RH), Department of Surgery, Division of Neurosurgery (CH), Department of Medicine, Division of Neurology (JM, NB), University of British Columbia, Vancouver, British Columbia, Canada; Forstrom-Jackson, Vancouver, British Columbia, Canada (PT).
Judy Allen, M.D., FRCPC
From the Department of Psychiatry (TAH, JA, CG, RH), Department of Surgery, Division of Neurosurgery (CH), Department of Medicine, Division of Neurology (JM, NB), University of British Columbia, Vancouver, British Columbia, Canada; Forstrom-Jackson, Vancouver, British Columbia, Canada (PT).
Caroline Gosselin, M.D., FRCPC
From the Department of Psychiatry (TAH, JA, CG, RH), Department of Surgery, Division of Neurosurgery (CH), Department of Medicine, Division of Neurology (JM, NB), University of British Columbia, Vancouver, British Columbia, Canada; Forstrom-Jackson, Vancouver, British Columbia, Canada (PT).
Robert Hewko, M.D., FRCPC
From the Department of Psychiatry (TAH, JA, CG, RH), Department of Surgery, Division of Neurosurgery (CH), Department of Medicine, Division of Neurology (JM, NB), University of British Columbia, Vancouver, British Columbia, Canada; Forstrom-Jackson, Vancouver, British Columbia, Canada (PT).
Jeff Martzke, Ph.D., RPsych
From the Department of Psychiatry (TAH, JA, CG, RH), Department of Surgery, Division of Neurosurgery (CH), Department of Medicine, Division of Neurology (JM, NB), University of British Columbia, Vancouver, British Columbia, Canada; Forstrom-Jackson, Vancouver, British Columbia, Canada (PT).
Nicholas Bogod, Ph.D., RPsych
From the Department of Psychiatry (TAH, JA, CG, RH), Department of Surgery, Division of Neurosurgery (CH), Department of Medicine, Division of Neurology (JM, NB), University of British Columbia, Vancouver, British Columbia, Canada; Forstrom-Jackson, Vancouver, British Columbia, Canada (PT).
Patricia Taylor, B.A., LLB
From the Department of Psychiatry (TAH, JA, CG, RH), Department of Surgery, Division of Neurosurgery (CH), Department of Medicine, Division of Neurology (JM, NB), University of British Columbia, Vancouver, British Columbia, Canada; Forstrom-Jackson, Vancouver, British Columbia, Canada (PT).

Notes

Address correspondence to Trevor Hurwitz, Dept. of Psychiatry, UBC Hospital, Vancouver, B.C., Canada; e-mail: [email protected]

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