Skip to main content
Full access
Clinical and Research Reports
Published Online: 1 January 2013

BDNF val66met Polymorphism Is Associated With Age at Onset and Intensity of Symptoms of Paranoid Schizophrenia in a Polish Population

Publication: The Journal of Neuropsychiatry and Clinical Neurosciences

Abstract

The brain-derived neurotrophic factor (BDNF) is one of the candidate genes for schizophrenia. There is evidence that val66met polymorphism may be involved in the pathophysiology of schizophrenia. The authors genotyped val66met (rs6265) polymorphism of the BDNF gene in 208 inpatients with paranoid schizophrenia and 254 control subjects in a Polish population. There was no association between val66met polymorphism and development of paranoid schizophrenia in either men or women. However, an association was found between this polymorphism and age at onset and psychopathology of paranoid schizophrenia. Men with the val/met genotype had an earlier age at onset, and the val/val genotype predisposed to more severe symptoms, particularly on the General Psychopathology Scale of the Positive and Negative Symptoms Scale (PANSS-G). The analysis of PANSS single items has shown that patients with the val/met genotype had higher scores on a hallucinatory behavior item than those with other genotypes.

Formats available

You can view the full content in the following formats:

Information & Authors

Information

Published In

Go to The Journal of Neuropsychiatry and Clinical Neurosciences
Go to The Journal of Neuropsychiatry and Clinical Neurosciences
The Journal of Neuropsychiatry and Clinical Neurosciences
Pages: 88 - 94
PubMed: 23487199

History

Received: 5 October 2011
Revision received: 17 December 2011
Accepted: 26 May 2012
Published online: 1 January 2013
Published in print: Winter 2013

Authors

Details

Renata Suchanek, Ph.D.
Dept. of Medical Genetics, Medical University of Silesia, Sosnowiec, Poland (RS, MPS, MK, JK); Division of Statistics, Dept. of Instrumental Analysis, Medical University of Silesia, Sosnowiec, Poland (AO); Dept. of Psychiatry and Psychotherapy, Medical University of Silesia, Katowice, Poland (KK).
Aleksander Owczarek, Ph.D.
Dept. of Medical Genetics, Medical University of Silesia, Sosnowiec, Poland (RS, MPS, MK, JK); Division of Statistics, Dept. of Instrumental Analysis, Medical University of Silesia, Sosnowiec, Poland (AO); Dept. of Psychiatry and Psychotherapy, Medical University of Silesia, Katowice, Poland (KK).
Monika Paul-Samojedny, Ph.D.
Dept. of Medical Genetics, Medical University of Silesia, Sosnowiec, Poland (RS, MPS, MK, JK); Division of Statistics, Dept. of Instrumental Analysis, Medical University of Silesia, Sosnowiec, Poland (AO); Dept. of Psychiatry and Psychotherapy, Medical University of Silesia, Katowice, Poland (KK).
Małgorzata Kowalczyk, Ph.D.
Dept. of Medical Genetics, Medical University of Silesia, Sosnowiec, Poland (RS, MPS, MK, JK); Division of Statistics, Dept. of Instrumental Analysis, Medical University of Silesia, Sosnowiec, Poland (AO); Dept. of Psychiatry and Psychotherapy, Medical University of Silesia, Katowice, Poland (KK).
Krzysztof Kucia, Ph.D.
Dept. of Medical Genetics, Medical University of Silesia, Sosnowiec, Poland (RS, MPS, MK, JK); Division of Statistics, Dept. of Instrumental Analysis, Medical University of Silesia, Sosnowiec, Poland (AO); Dept. of Psychiatry and Psychotherapy, Medical University of Silesia, Katowice, Poland (KK).
Jan Kowalski, Prof.
Dept. of Medical Genetics, Medical University of Silesia, Sosnowiec, Poland (RS, MPS, MK, JK); Division of Statistics, Dept. of Instrumental Analysis, Medical University of Silesia, Sosnowiec, Poland (AO); Dept. of Psychiatry and Psychotherapy, Medical University of Silesia, Katowice, Poland (KK).

Notes

Send correspondence to Renata Suchanek, Ph.D.; e-mail: [email protected]

Metrics & Citations

Metrics

Citations

Export Citations

If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download.

For more information or tips please see 'Downloading to a citation manager' in the Help menu.

Format
Citation style
Style
Copy to clipboard

View Options

View options

PDF/ePub

View PDF/ePub

Full Text

View Full Text

Get Access

Login options

Already a subscriber? Access your subscription through your login credentials or your institution for full access to this article.

Personal login Institutional Login Open Athens login
Purchase Options

Purchase this article to access the full text.

PPV Articles - Journal of Neuropsychiatry and Clinical Neurosciences

PPV Articles - Journal of Neuropsychiatry and Clinical Neurosciences

Not a subscriber?

Subscribe Now / Learn More

PsychiatryOnline subscription options offer access to the DSM-5-TR® library, books, journals, CME, and patient resources. This all-in-one virtual library provides psychiatrists and mental health professionals with key resources for diagnosis, treatment, research, and professional development.

Need more help? PsychiatryOnline Customer Service may be reached by emailing [email protected] or by calling 800-368-5777 (in the U.S.) or 703-907-7322 (outside the U.S.).

Media

Figures

Other

Tables

Share

Share

Share article link

Share