Serious mental illness is an intriguing group of brain disorders, usually involving psychosis and often mania, where each conventional diagnosis has a weak knowledge base to support disease understanding and all have been highly resistant to disease discovery. While it is easy to say that we ought to base medication development on known neural defects, psychiatry has been very slow and clumsy at broadly implementing this strategy and, frankly, has not been effective enough at generating novel drugs for these disorders.
