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Center for Workplace Mental Health

Depression: A Costly Condition for Businesses: Learn more and view the infographic

Help With Depression

Depression (major depressive disorder) is a common and serious medical illness that negatively affects how you feel, the way you think and how you act. Fortunately, it is also treatable. Learn More

American Journal of Psychiatry, Volume 177, Issue 5


The American Journal of Psychiatry

The Rearing Environment and Risk for Major Depression: A Swedish National High-Risk Home-Reared and Adopted-Away Co-Sibling Control Study

Kenneth S. Kendler, M.D., Henrik Ohlsson, Ph.D., Jan Sundquist, M.D., Ph.D., Kristina Sundquist, M.D., Ph.D.

Is Depression Nature or Nurture? Yes

Myrna M. Weissman, Ph.D.

More from APA: A Child’s Home Environment Can Impact the Risk of Developing Depression

Gabbard’s Treatments of Psychiatric Disorders, 5th Edition

Gabbard’s Treatments of Psychiatric Disorders Chapter 14 of this textbook reviews the pharmacological landscape and experimental horizon in Major Depressive Disorder (MDD).

Continue reading online in Chapter 14: Pharmacological and Somatic Treatments for Major Depressive Disorder.

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What Is Depression?

Depression (major depressive disorder) is a common and serious medical illness that negatively affects how you feel, the way you think and how you act.

Fortunately, it is also treatable. Depression causes feelings of sadness and/or a loss of interest in activities once enjoyed. It can lead to a variety of emotional and physical problems and can decrease a person’s ability to function at work and at home.

Learn More

Browse APA journals and books to view relevant content on MDD and narrow results or sort by publication date

Patient Story: Depression

Trish was a 51-year-old woman who was brought to the emergency room by her husband. She said, “I feel like killing myself.” She had lost her interest in life about four months before. During that time, she reported depression every day for most of the day. Symptoms had been getting worse for months... continue reading

About This Story
This patient story is excerpted from Understanding Mental Disorders: A Patient And Family Resource.

Based on the latest, fifth edition of the Diagnostic and Statistical Manual of Mental Disorders—known as DSM-5®—Understanding Mental Disorders provides valuable insight on what to expect from an illness and its treatment—and will help readers recognize symptoms, know when to seek help, and get the right care.

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Go to Understanding Mental Disorders: A Patient and Family Resource
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Find a Psychiatrist

A psychiatrist specializes in the diagnosis, treatment, and prevention of mental illness and substance abuse disorders. Psychiatrists are uniquely qualified to understand the complex interrelation between mental and physical health since their training includes four years of medical school and at least three additional years in a psychiatric residency.

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Seasonal Affective Disorder

Learn about Seasonal Affective Disorder, including symptoms, risk factors and treatment options.

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Expert Q & A: Depression

Find answers to your questions about depression written by leading psychiatrists.

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