BRAIN LESIONS ASSOCIATED WITH EXPERIMENTAL "EPILEPTIFORM" SEIZURES IN THE MONKEY

S. EUGENE BARRERA, LENORE M. KOPELOFF, and NICHOLAS KOPELOFFAuthors Info & Affiliations

Publication: American Journal of Psychiatry

Volume 100, Number 7

https://doi.org/10.1176/ajp.100.7.727

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Abstract

By means of a single application to the cerebral motor cortex of certain chemical and immunologic agents, it has been possible to produce convulsive seizures in the rhesus monkey. Of more significance than the acute manifestations observed, was the state of chronic convulsive reactivity induced.

A histopathologic examination of monkeys exhibiting recurrent convulsive seizures indicated a pathologic process which was essentially that of a chronic progressive meningocortical cicatrix. However, a similar type of lesion was produced by control preparations which failed to induce convulsive seizures at any time during a long observation period.

From this study it must be concluded that the pathologic changes observed were insufficient to account by themselves for the convulsive manifestations.

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Information & Authors

Information

Published In

American Journal of Psychiatry

Volume 100 • Number 7 • May 1944

Pages: 727 - 737

History

Published in print: May 1944

Published online: 1 April 2006

Authors

Details

S. EUGENE BARRERA

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LENORE M. KOPELOFF

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NICHOLAS KOPELOFF

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The Department of Research Psychiatry and the Department of Bacteriology, New York State Psychiatric Institute and Hospital, New York, N. Y., Professor of Neurology and Psychiatry, Albany Medical College, and Neurologist and Psychiatrist-in-Chief, Albany Hospital, Albany, N. Y.

The Department of Research Psychiatry and the Department of Bacteriology, New York State Psychiatric Institute and Hospital, New York, N. Y.

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BRAIN LESIONS ASSOCIATED WITH EXPERIMENTAL "EPILEPTIFORM" SEIZURES IN THE MONKEY

Abstract

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