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Published Online: December 1948

PRACTICAL ASPECTS OF MESANTOIN THERAPY IN EPILEPSY

JOSEPH L. FETTERMAN and VICTOR M. VICTOROFFAuthors Info & Affiliations

Publication: American Journal of Psychiatry

Volume 105, Number 6

https://doi.org/10.1176/ajp.105.6.410

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Abstract

1. Two years' experience with Mesantoin shows it to be a highly valuable anticonvulsant drug. It can be used alone in the control of grand mal, especially Jacksonian attacks. It may be of some benefit in psychomotor seizures.

2. We have found that Mesantoin is best combined with dilantin sodium. Dilantin sodium is still perhaps the most effective anticonvulsant remedy and should be the base upon which other drugs are added.

3. The dosage of Mesantoin and dilantin sodium must be individualized and adjusted to the need of the patient. May we impress the goal of a limited number of spells, not a reduced number of pills.

4. A common effective dose for adults is dilantin sodium 1 to 3 capsules, and mesantoin, 4 to 6 tablets daily. This combination has proved more effective in controlling seizures than any previous single drug or combined drugs which we have used.

5. Side actions of Mesantoin include drowsiness and skin rash. As a rule patients acquire tolerance to the drowsiness in a period of time. Dexedrine and physical activity tend to free the patients from the somnolence.

6. Effective control of an epileptic requires close and continued observation and treatment.

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Information & Authors

Information

Published In

American Journal of Psychiatry

Volume 105 • Number 6 • December 1948

Pages: 410 - 416

PubMed: 18894625

History

Published in print: December 1948

Published online: 1 April 2006

Authors

Affiliations

JOSEPH L. FETTERMAN

The Fetterman Clinic, Cleveland, Ohio.

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VICTOR M. VICTOROFF

The Fetterman Clinic, Cleveland, Ohio.

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PRACTICAL ASPECTS OF MESANTOIN THERAPY IN EPILEPSY

Abstract

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