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Published Online: February 1952

EXPERIMENTAL SCHIZOPHRENIA-LIKE SYMPTOMS

MAX RINKEL, H. JACKSON DESHON, ROBERT W. HYDE, and HARRY C. SOLOMONAuthors Info & Affiliations

Publication: American Journal of Psychiatry

Volume 108, Number 8

https://doi.org/10.1176/ajp.108.8.572

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Abstract

1. The effects of minute amounts of dlysergic acid diethylamide tartrate (L. S. D.) on normal subjects, with an age range of 19-48 years, and some psychotic patients of the schizophrenic, depressive, and paranoic type are reported.

2. Psychotic phenomena and alterations of the autonomic nervous system were observed. The psychotic phenomena were predominantly schizophrenia-like symptoms that were manifested in disturbances of thought and speech; changes in affect and mood; perception; production of hallucinations and delusions; depersonalization and changes in behavior. The basic intelligence was not reduced.

3. Electroencephalographic examinations at the height of the L.S.D. reaction revealed only slight changes, principally increased alpha rhythm, except in one case where there occurred a slowing of about 2 cycles per second.

4. Rorschach tests showed abnormalities principally of the schizophrenic or paranoic type. Concrete-abstract thinking tests also, on the whole, showed responses similar to those obtained in schizophrenic patients.

5. No scientific theory for the origination of the natural psychotic phenomena or psychoses is being advanced, but the belief is expressed that experimental psychiatry progresses in the right direction.

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Information & Authors

Information

Published In

American Journal of Psychiatry

Volume 108 • Number 8 • February 1952

Pages: 572 - 578

PubMed: 14903182

History

Published in print: February 1952

Published online: 1 April 2006

Authors

Affiliations

MAX RINKEL

The Department of Psychiatry, Harvard Medical School, and the Boston Psychopathic Hospital

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H. JACKSON DESHON

The Department of Psychiatry, Harvard Medical School, and the Boston Psychopathic Hospital

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ROBERT W. HYDE

The Department of Psychiatry, Harvard Medical School, and the Boston Psychopathic Hospital

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HARRY C. SOLOMON

The Department of Psychiatry, Harvard Medical School, and the Boston Psychopathic Hospital

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EXPERIMENTAL SCHIZOPHRENIA-LIKE SYMPTOMS

Abstract

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