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Published Online: May 1956

PSYCHOSIS AND ALLERGY: EXPERIMENTAL APPROACH

DANIEL X. FREEDMAN, F. C. REDLICH, and WALTER W. IGERSHEIMERAuthors Info & Affiliations

Publication: American Journal of Psychiatry

Volume 112, Number 11

https://doi.org/10.1176/ajp.112.11.873

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Abstract

1. Twenty-two schizophrenic patients and 22 preclinical medical students were skin tested with a battery of allergens, histamine and cantharides, to test experimentally the hypothesis that psychosis involves diminished ability to react allergically.

2. The patient group showed no diminished ability to react allergically when compared with controls, but did have consistently smaller wheal response to histamine.

3. It is suggested that while neither hypoergic nor hyporeactive in the skin, the schizophrenic patient may differ from the normal with respect to certain links in the allergic process, and may so differ without of necessity clinically manifesting this.

4. Alteration in central nervous system function in schizophrenia—possibly diencephalic or reticular—may account for the differences in histamine response and the reported differences in autonomic responsivity, in ability contemporaneously to develop sensitization and to respond to antigen with high titre of antibodies.

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Information & Authors

Information

Published In

American Journal of Psychiatry

Volume 112 • Number 11 • May 1956

Pages: 873 - 877

PubMed: 13313785

History

Published in print: May 1956

Published online: 1 April 2006

Authors

Details

DANIEL X. FREEDMAN

The Department of Psychiatry, School of Medicine, Yale University.

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F. C. REDLICH

The Department of Psychiatry, School of Medicine, Yale University.

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WALTER W. IGERSHEIMER

The Department of Psychiatry, School of Medicine, Yale University.

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PSYCHOSIS AND ALLERGY: EXPERIMENTAL APPROACH

Abstract

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