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Published Online: March 1958

TWO YEAR FOLLOW-UP STUDY OF THE RELATIONSHIP OF CHLORPROMAZINE AND THE INCIDENCE OF CONVULSIONS IN FIFTY POST-LOBOTOMY PATIENTS

A. E. PAGANINI and M. ZLOTLOWAuthors Info & Affiliations

Publication: American Journal of Psychiatry

Volume 114, Number 9

https://doi.org/10.1176/ajp.114.9.839

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Abstract

Our 2 year follow-up study of 50 post-lobotomy patients and the incidence of convulsions with chlorpromazine therapy reveals the following conclusions:

1. Chlorpromazine did not increase the frequency of convulsions in post-lobotomy patients who have a convulsive background.

2. In post-lobotomy patients who never had convulsions, chlorpromazine did not produce convulsions but the possibility of a "masked fit" in one case of sudden death must be entertained.

3. In patients who have a history of convulsions, the seizures seemed to occur within 2-4 weeks of the institution of therapy but the number of fits seems to be decreasing. This may indicate a probable synergistic action between the anti-convulsants and chlorpromazine.

4. Anti-convulsants should be continued while the patient is on chlorpromazine if there is a history of convulsions.

5. In our opinion, there is no contra-indication or risk in the use of chlorpromazine for the relief of psychotic symptoms in post-lobotomy patients providing convulsive patients are continued on anti-convulsants.

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Information & Authors

Information

Published In

American Journal of Psychiatry

Volume 114 • Number 9 • March 1958

Pages: 839 - 840

PubMed: 13508912

History

Published in print: March 1958

Published online: 1 April 2006

Authors

Details

A. E. PAGANINI

Pilgrim State Hospital, West Brentwood, N. Y.

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M. ZLOTLOW

Pilgrim State Hospital, West Brentwood, N. Y.

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TWO YEAR FOLLOW-UP STUDY OF THE RELATIONSHIP OF CHLORPROMAZINE AND THE INCIDENCE OF CONVULSIONS IN FIFTY POST-LOBOTOMY PATIENTS

Abstract

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