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Published Online: May 1962

RELATIONS BETWEEN ENERGY TRANSFER SYSTEMS AND THE SYMPTOMS OF SCHIZOPHRENIA

PETER G. S. BECKETT, RITA SENF, CHARLES E. FROHMAN, GARFIELD TOURNEY, and JACQUES S. GOTTLIEBAuthors Info & Affiliations

Publication: American Journal of Psychiatry

Volume 118, Number 11

https://doi.org/10.1176/ajp.118.11.995

Abstract

1. Intracellular energy producing metabolic systems were investigated in erythrocytes before and after insulin stress in 10 control, 10 acute schizophrenic, and 10 chronic schizophrenic male subjects.

2. Following complete clinical study 28 ratings of symptoms and course of illness were made for each subject.

3. Correlation coefficients (r's) were computed between the biochemical and clinical variables.

4. It was found that the primary symptoms were directly related to the failure of mobilization after stress of the compound fructose-1,6-diphosphate.

5. In contrast, the secondary symptoms were not significantly related to biochemical variables.

6. Scores indicating a chronic illness and a poor outcome at followup were found to be directly related to another very important substance in this metabolic scheme. This substance is adenosine triphosphate (ATP).

7. The possible significance of these findings is discussed in relation to a hypothetical serum factor in schizophrenia.

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Published In

Go to American Journal of Psychiatry

Go to American Journal of Psychiatry

American Journal of Psychiatry

Volume 118 • Number 11 • May 1962

Pages: 995 - 1003

PubMed: 13866416

History

Published in print: May 1962

Published online: 1 April 2006

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Details

PETER G. S. BECKETT

The Lafayette Clinic and Wayne State University, College of Medicine, Detroit, Mich.

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RITA SENF

The Lafayette Clinic and Wayne State University, College of Medicine, Detroit, Mich.

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CHARLES E. FROHMAN

The Lafayette Clinic and Wayne State University, College of Medicine, Detroit, Mich.

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GARFIELD TOURNEY

The Lafayette Clinic and Wayne State University, College of Medicine, Detroit, Mich.

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JACQUES S. GOTTLIEB

The Lafayette Clinic and Wayne State University, College of Medicine, Detroit, Mich.

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