NEUROPATHY, AGRANULOCYTOSIS, AND HEPATO-TOXICITY FOLLOWING IMIPRAMINE THERAPY

MORTON MILLERAuthors Info & Affiliations

Publication: American Journal of Psychiatry

Volume 120, Number 2

https://doi.org/10.1176/ajp.120.2.185

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Abstract

Bilateral peroneal nerve palsy, agranulocytosis, and hepato-toxicity following imipramine administration, with improvement after cessation of the drug, were observed. Laboratory tests seemed to rule out other possible sources of the symptoms noted. The 5 previously reported cases of motor neuropathy appearing during imipramine therapy are similar in that they all involved elderly persons, and were restricted to the lower extremities. Complete remission of neurologic symptoms is not universal. Considering recent experience with thalidomide, the large variety of neurotoxic side effects seen with imipramine would merit caution in the use of this agent in pregnancy.

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Information & Authors

Information

Published In

American Journal of Psychiatry

Volume 120 • Number 2 • August 1963

Pages: 185 - 186

History

Published in print: August 1963

Published online: 1 April 2006

Authors

Affiliations

MORTON MILLER

Yale University, School of Medicine, New Haven, Conn.

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NEUROPATHY, AGRANULOCYTOSIS, AND HEPATO-TOXICITY FOLLOWING IMIPRAMINE THERAPY

Abstract

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