CLINICAL TRIAL OF DESIPRAMINE IN THE TREATMENT OF DEPRESSION

THAD J. BARRINGERAuthors Info & Affiliations

Publication: American Journal of Psychiatry

Volume 121, Number 11

https://doi.org/10.1176/ajp.121.11.1117

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Abstract

Thirty severely depressed patients received daily oral doses of 75 or 100 mg. desipramine, a metabolite of imipramine. Duration of therapy averaged 3 to 4 months and dosage was decreased gradually according to individual progress. Tranquilizers were used as required to control anxiety, insomnia or agitation, and psychotherapy was given at the level indicated.

Most patients had a history of several depressive episodes, hospitalizations, ECT, or poor response to numerous other drugs.

In 24 patients (80%) desipramine produced a satisfactory clinical response. The new drug exerted a faster onset of action (usually 2 to 7 days) and fewer, milder side effects compared to previous use of imipramine.

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Information & Authors

Information

Published In

American Journal of Psychiatry

Volume 121 • Number 11 • May 1965

Pages: 1117 - 1119

PubMed: 14283314

History

Published in print: May 1965

Published online: 1 April 2006

Authors

Details

THAD J. BARRINGER

800 St. Mary's Street, Raleigh, North Carolina

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CLINICAL TRIAL OF DESIPRAMINE IN THE TREATMENT OF DEPRESSION

Abstract

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