CLINICAL TRIAL OF A NEW ANTIDEPRESSANT (DESIPRAMINE HYDROCHLORIDE) IN A HOSPITAL SETTING

ANTHONY LAPOLLAAuthors Info & Affiliations

Publication: American Journal of Psychiatry

Volume 121, Number 12

https://doi.org/10.1176/ajp.121.12.1206

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Abstract

Desipramine, the monomethyl metabolite of imipramine, was used as the basic treatment of 20 patients with severe or moderately severe depression. A fixed dose of 50 mg. q.i.d. was given, and drug effects were evaluated in terms of changes in target symptoms, onset of action and side effects.

Complete remission or improvement permitting discharge from hospital was obtained in 14 patients (70%). The time to onset of observable response averaged 2 days, while peak antidepressant action occurred after an average of 5.5 days.

Side effects were encountered in one patient and consisted of gastro-intestinal upset, dry mouth and drowsiness. Medication was discontinued in this case. No significant effects on blood pressure, peripheral blood picture, urine or liver function were observed.

Desipramine appeared to be an effective and well-tolerated antidepressant similar in its activity to imipramine. With the substantial initial dosage used, the relatively prompt onset of action seems to be the prime advantage of the drug in treating serious depressions.

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Information & Authors

Information

Published In

American Journal of Psychiatry

Volume 121 • Number 12 • June 1965

Pages: 1206 - 1208

PubMed: 14286058

History

Published in print: June 1965

Published online: 1 April 2006

Authors

Affiliations

ANTHONY LAPOLLA

Santa Barbara, Calif.

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CLINICAL TRIAL OF A NEW ANTIDEPRESSANT (DESIPRAMINE HYDROCHLORIDE) IN A HOSPITAL SETTING

Abstract

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