Clinical Significance of Anticholinergic Effects of Imipramine-Like Drugs

GEORGE E. VAILLANTAuthors Info & Affiliations

Publication: American Journal of Psychiatry

Volume 125, Number 11

https://doi.org/10.1176/ajp.125.11.1600

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Abstract

The author compared the antimuscarinic effects on pigeon behavior of amitriptyline, imipramine, and desmethylimipramine (DMI), as well as several other drugs. The results, which did not support the hypothesis that discrete cholinergic mechanisms play an important role in endogenous depression, suggest that DMI may be the antidepressant of choice when the physician wants to minimize atropine-like side effects, while amitriptyline may be chosen when a sedative effect is desired.

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Information & Authors

Information

Published In

American Journal of Psychiatry

Volume 125 • Number 11 • May 1969

Pages: 1600 - 1602

PubMed: 5769289

History

Published in print: May 1969

Published online: 1 April 2006

Authors

Affiliations

GEORGE E. VAILLANT

Department of psychiatry, Tufts University School of Medicine, 260 Tremont St., Boston, Mass. 02116

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Clinical Significance of Anticholinergic Effects of Imipramine-Like Drugs

Abstract

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