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Published Online: December 1973

Plasma Binding of Imipramine and Clinical Outcome

ALEXANDER H. GLASSMAN, MARIA J. HURWIC, and JAMES M. PERELAuthors Info & Affiliations

Publication: American Journal of Psychiatry

Volume 130, Number 12

https://doi.org/10.1176/ajp.130.12.1367

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Abstract

The binding of imipramine to plasma protein was examined in 26 depressed patients. In contrast to the findings of previously published reports, the fraction of the drug that remained unbound was found to vary significantly from one patient to another. This finding provides a possible explanation for the discrepancies that have been found in studies that have attempted to correlate plasma levels of antidepressant drugs and clinical outcome.

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Information & Authors

Information

Published In

American Journal of Psychiatry

Volume 130 • Number 12 • December 1973

Pages: 1367 - 1369

PubMed: 4754681

History

Published in print: December 1973

Published online: 1 April 2006

Authors

Details

ALEXANDER H. GLASSMAN

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MARIA J. HURWIC

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JAMES M. PEREL

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Acting Director, Department of Biological Psychiatry, New York State Psychiatric Institute, 722 West 168th St., New York. N.Y. 10032

Senior Research Scientist, Department of Biological Psychiatry, New York State Psychiatric Institute, 722 West 168th St., New York. N.Y. 10032

Associate Research Scientist and Laboratory Chief, Department of Biological Psychiatry, New York State Psychiatric Institute, 722 West 168th St., New York. N.Y. 10032

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Plasma Binding of Imipramine and Clinical Outcome

Abstract

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