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Research Article
Published Online: December 1986

Failure of buspirone to manage benzodiazepine withdrawal

Publication: American Journal of Psychiatry

Abstract

Fifteen patients with 146 cumulative years of tranquilizer use were withdrawn from their benzodiazepine (nine gradually and six abruptly), and buspirone, a new nonbenzodiazepine anxiolytic, was substituted. The addition of buspirone did not appear to lessen the intensity of the withdrawal state. This finding supports preclinical studies indicating that buspirone has no clinically significant benzodiazepine receptor activity.

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Go to American Journal of Psychiatry
Go to American Journal of Psychiatry
American Journal of Psychiatry
Pages: 1590 - 1592
PubMed: 2878622

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Published in print: December 1986
Published online: 1 April 2006

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