Facilitation of ECT by caffeine pretreatment

Publication: American Journal of Psychiatry

https://doi.org/10.1176/ajp.144.9.1199

Abstract

In this study, eight patients participated in a standardized protocol to assess the effects of caffeine on seizures in ECT. Caffeine sodium benzoate (500-2000 mg) was administered intravenously 10 minutes before ECT, and seizure duration was compared with that of a previous treatment unmodified by caffeine. Seizure duration was significantly increased during ECTs preceded by caffeine. Three other patients given caffeine when seizures of adequate duration could no longer be elicited at maximal stimulus levels experienced longer seizures. Administration of caffeine was not associated with significant cardiovascular or other (including cognitive) adverse effects.

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Published In

American Journal of Psychiatry

Volume 144 • Number 9 • September 1987

Pages: 1199 - 1202

PubMed: 3631318

History

Published in print: September 1987

Published online: 1 April 2006

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Facilitation of ECT by caffeine pretreatment

Abstract

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