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Research Article
Published Online: January 1989

Clonazepam treatment of five lithium-refractory patients with bipolar disorder

Publication: American Journal of Psychiatry

Abstract

The authors describe the first five patients enrolled in an open clinical trial of clonazepam as a maintenance treatment in lithium- refractory bipolar disorder. All patients relapsed quickly after taking clonazepam (one within 2 weeks and four within 10-15 weeks), and the study was prematurely terminated. The results cast doubt over the usefulness of clonazepam as a prophylaxis in lithium-resistant bipolar patients who have histories of psychotic mania or delusional depression.

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Go to American Journal of Psychiatry
Go to American Journal of Psychiatry
American Journal of Psychiatry
Pages: 77 - 80
PubMed: 2643359

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Published in print: January 1989
Published online: 1 April 2006

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