Observed Effects of Creatine Monohydrate in a Patient With Depression and Fibromyalgia

“Ms. A” was a 52-year-old woman who suffered from posttraumatic stress disorder (PTSD), depression, and fibromyalgia. She had been a highly functioning woman who ran a kindergarten. Her psychiatric condition started after she lost her left eye in a terror bombing scene. Therapy with citalopram, 40 mg/day and tramadolol, 200 mg/day, for more than a year was ineffective, and she continued to suffer from severe symptoms of the aforementioned disorders.

The patient participated in an open study for 4 weeks that examined the effect of creatine monohydrate added to the ongoing psychotropic treatment of PTSD patients (5) . In addition to the assessment of her PTSD, Ms. A was evaluated three times during this period (prior to participation and 2 and 4 weeks after) using the Hamilton Rating Scale for Depression and the Short Form 36 Health Status Questionnaire, assessing quality of life. Pain was assessed using the Visual Analog Scale.

Tender-point count was performed manually. The patient was asked to indicate when the sensation altered from pressure to definite pain at predefined anatomical sites according to the American College of Rheumatology classification criteria for fibromyalgia. All points were painful.

The patient was treated with creatine monohydrate for 4 weeks (3 g daily in the first week, then 5 g daily). Ongoing psychotropic treatment was not altered during the study.

The patient showed improvement in the symptoms of depression (Hamilton depression scale scores decreased from 24 to 16) and fibromyalgia (Visual Analog Scale score decreased from 80 to 40). This moderate recovery may be ascribed to the improvement of her sleep patterns and somatic symptoms (directly affecting the outcome of her Hamilton depression scale scores). Her quality of life improved as well, measured by a change of 30% on her total Short Form-36 score. Although the number of her tender points remained constant, they were less tender, and she was able to function more and sleep better, without being disturbed by pain. By request, she continued to consume creatine following the termination of the study, and 8 weeks following recruitment to the study, the beneficial effect remained.