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Published Online: January 1940

DETOXICATION OF SODIUM BENZOATE IN NEUROPSYCHIATRIC DISORDERS : The Excretion of Hippuric Acid After the Ingestion of Sodium Benzoate.

ISIDORE FINKELMAN, JERRY HORA, IRVING C. SHERMAN, and M. K. HORWITTAuthors Info & Affiliations

Publication: American Journal of Psychiatry

Volume 96, Number 4

https://doi.org/10.1176/ajp.96.4.951

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Abstract

The rate of detoxication of benzoic acid was determined in patients with various neuropsychiatric diseases. About one half of the patients with catatonia showed a defect in hippuric acid synthesis. This may be due to the state of muscular rigidity and immobility of these patients. Deteriorated patients with epilepsy showed a defect in the synthesis of hippuric acid, whereas extramural patients with epilepsy showed a normal excretion of the equivalent benzoic acid. This may indicate a defect in glycine synthesis in deteriorated patients with epilepsy. Normal average values were found in post-encephalitic Parkinsonism and multiple sclerosis. A patient with progressive muscular dystrophy was able to synthesize glycine at a normal rate.

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Information & Authors

Information

Published In

American Journal of Psychiatry

Volume 96 • Number 4 • January 1940

Pages: 951 - 960

History

Published in print: January 1940

Published online: 1 April 2006

Authors

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ISIDORE FINKELMAN

The Department of Nervous and Mental Diseases, Northwestern University Medical School and the Elgin State Hospital.

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JERRY HORA

The Department of Nervous and Mental Diseases, Northwestern University Medical School and the Elgin State Hospital.

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IRVING C. SHERMAN

The Department of Nervous and Mental Diseases, Northwestern University Medical School and the Elgin State Hospital.

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M. K. HORWITT

The Department of Nervous and Mental Diseases, Northwestern University Medical School and the Elgin State Hospital.

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DETOXICATION OF SODIUM BENZOATE IN NEUROPSYCHIATRIC DISORDERS : The Excretion of Hippuric Acid After the Ingestion of Sodium Benzoate.

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