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Published Online: November 1941

BRAIN METABOLISM, VIII : The Effects of Electric Shock and Some Newer Drugs

S. BERNARD WORTIS, DONALD SHASKAN, DAVID IMPASTATO, and RENATO ALMANSIAuthors Info & Affiliations

Publication: American Journal of Psychiatry

Volume 98, Number 3

https://doi.org/10.1176/ajp.98.3.354

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Abstract

1. Adrenalin, caffeine and cocaine, in high concentrations in the dextrose substrate, inhibit oxygen uptake, whereas nicotine has no such effect.

2. Picrotoxin, prostigmine and tyramine when injected subcutaneously into the rat, tend to increase brain oxygen uptake in plain Ringer's phosphate.

3. Dextrose has a protective action against the depressive effect of drugs.

4. Electrical convulsions inhibit oxygen uptake; this effect is greater after repeated shocks and is more marked in the dextrose substrate.

5. Electrical convulsions and to a greater extent, insulin, interfere with oxygen uptake, in contrast to metrazol and camphor which are metabolic stimulants. The availability or utilizability of dextrose by the brain may account for this difference.

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Information & Authors

Information

Published In

American Journal of Psychiatry

Volume 98 • Number 3 • November 1941

Pages: 354 - 359

History

Published in print: November 1941

Published online: 1 April 2006

Authors

Affiliations

S. BERNARD WORTIS

The Laboratory of Experimental Neurology, New York University College of Medicine and the Department of Neurology, New York University College of Medicine.

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DONALD SHASKAN

The Laboratory of Experimental Neurology, New York University College of Medicine and the Department of Neurology, New York University College of Medicine.

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DAVID IMPASTATO

The Laboratory of Experimental Neurology, New York University College of Medicine and the Department of Neurology, New York University College of Medicine.

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RENATO ALMANSI

The Laboratory of Experimental Neurology, New York University College of Medicine and the Department of Neurology, New York University College of Medicine.

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BRAIN METABOLISM, VIII : The Effects of Electric Shock and Some Newer Drugs

Abstract

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