Tranylcypromine: Its Pharmacology, Safety, and Efficacy
Abstract
Review of Pharmacology
Enzyme | Distribution | Substrate | ||||
---|---|---|---|---|---|---|
Isoform | Brain | Gut | 5-HT | NE | DA | Tyr |
MAO-A | Yes | Yes | Yes | Yes | Yes | Yes |
MAO-B | Yes | Yes |
Clinical Efficacy
Treatment-Resistant Depression
Atypical Depression
Starting Patients on Tranylcypromine
Augmentation Strategies
Drug Interactions
Antidepressants and Mood Stabilizers
Stimulants
Adverse Effects
Drug | Side effect | Comments |
---|---|---|
Nonhydrazine | ||
Tranylcypromine | Orthostasis, dizziness, dry mouth, insomnia | Inhibits tyramine catabolism, associated with transient post-dose hypertension |
Hydrazine | ||
Phenelzine | Orthostasis, dizziness, weight gain, sexual dysfunction, edema, sedation | Inhibits tyramine catabolism, has been associated with hepatotoxicity, potential risk for pyridoxine (B6) deficiency, CYP 2C19 and 2B6 inhibition |
Isocarboxazid | Orthostasis, dizziness, weight gain, sexual dysfunction, edema | Inhibits tyramine catabolism, potential risk for hepatotoxicity, potential risk for pyridoxine (B6) deficiency |
Effects on Blood Pressure
Tyramine Reaction
Conclusions
Key Points/Clinical Pearls
References
Information & Authors
Information
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History
Authors
Metrics & Citations
Metrics
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