Change in Brain Function With Placebo

ANDREW P. HO, M.D.Authors Info & Affiliations

Publication: American Journal of Psychiatry

https://doi.org/10.1176/appi.ajp.160.2.387-b

To the Editor: I read the intriguing report by Andrew F. Leuchter et al., M.D. (1), of a comparison of brain quantitative electroencephalography (QEEG) in depressed subjects who received placebo and in those who received an antidepressant (fluoxetine or venlafaxine). For unknown reasons, the authors described the collection of QEEG measures at the end of the 1-week placebo lead-in period (1 week after baseline) but neglected to report these data.

According to the Hamilton Depression Rating Scale scores given in the article, much of the clinical improvement occurred early (by 1 week after baseline). If this is true, then QEEG data collected temporally closest to that transition could be the most informative. The most informative data from this study should not be left out of this article.

Reference

Leuchter AF, Cook IA, Witte EA, Morgan M, Abrams M: Changes in brain function of depressed subjects during treatment with placebo. Am J Psychiatry 2002; 159:122-129

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Information & Authors

Information

Published In

American Journal of Psychiatry

Volume 160 • Number 2 • February 2003

Pages: 387-b - 388

History

Published online: 1 February 2003

Published in print: February 2003

Authors

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ANDREW P. HO, M.D.

Beverly Hills, Calif.

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Change in Brain Function With Placebo

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