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The management of mental illness during pregnancy and lactation is a complicated clinical challenge encompassing two concomitant medical conditions (i.e., pregnancy and a psychiatric disorder) that requires consideration of the welfare of at least two patients (i.e., mother and child). Various nonpharmacological treatment options for maternal mental illnesses during the antepartum and postpartum periods are beyond the scope of this chapter. Viable treatment options must be available, accessible, affordable, and effective for the illness, and in many cases, this may involve pharmacotherapy. Unfortunately, definitive treatment guidelines for perinatal psychotropic medications remain unavailable. In the two decades since the initial iteration of this chapter, there has been an enormous expansion in the reproductive safety literature focusing on psychotropic medications.
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