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The onset, course, and outcomes of endocrine disorders traditionally have been linked to psychological and social factors. A growing body of neuroendocrine research has begun to illuminate important biological mechanisms underlying the interplay of psyche and soma, with important clinical ramifications. In this chapter, we focus primarily on these latter pragmatic issues. Diabetes mellitus is the most common endocrine condition and is growing in epidemic proportions, so it has been given major emphasis. Other topics include disturbances in thyroid, parathyroid, adrenal, growth, prolactin, and gonadal hormones; pheochromocytomas; and metabolic disorders including electrolyte and acid–base disturbances, vitamin deficiencies, osteoporosis, and inherited disorders including the porphyrias.
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