Chapter 29.Organ Transplantation
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Excerpt
Solid organ transplantation began in 1954, with a successful kidney transplant in a patient whose identical twin was the donor. For most patients, however, an identical-twin donor was not an option, and more than a decade passed before immunosuppressive medications were available to conquer the immunological barrier. In 1967, the first successful liver transplant was performed, followed a year later by the first successful heart transplant. Even though surgical challenges of solid organ transplantation had been overcome, it was not until the early 1980s, with the advent of improved immunosuppression, that organ transplantation changed from an experimental procedure to a standard of care for many types of end-stage organ disease.
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