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Chapter 3.Antidepressants

https://doi.org/10.1176/appi.books.9781615372997.AS03

Sections

History | General Principles of Antidepressant Use | Selective Serotonin Reuptake Inhibitors | Serotonin-Norepinephrine Reuptake Inhibitors (Venlafaxine, Desvenlafaxine, Duloxetine, Levomilnacipran, and Milnacipran) | 5-HT2 Receptor Antagonists (Trazodone and Nefazodone) | Combined Noradrenergic-Dopaminergic Antidepressant (Bupropion) | Mirtazapine | Vilazodone | Vortioxetine | Tricyclic and Tetracyclic Antidepressants | Monoamine Oxidase Inhibitors | Selective and Reversible Monoamine Oxidase Inhibitors | Novel and Evolving Antidepressant Agents | Other Novel/Future Antidepressants | Bibliography

Excerpt

According to the Centers for Disease Control and Prevention 2017 report “Antidepressant Use in Persons Age 12 and Over, United States,” 12.7% of the American population were taking a prescribed antidepressant in the past month (Pratt et al. 2017). The wisdom of such a widespread use of this class of medications is debated in the literature and the popular press. However, what is not debatable is that clinicians have felt increasingly comfortable in prescribing these medications over the past 30 years. The continued popularity of antidepressants rests on a number of factors, including their efficacy in the treatment of depression, broad spectrum of activity, relative safety, and ease of use. Factors such as marketing also have played a role in the widespread adoption of antidepressants in clinical practice.

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