Page numbers printed in boldface type refer to tables.
Abusein children,2
medical child abuse,114–115
Academy for Eating Disorders,155
Addiction psychiatry, harm reduction and,144
Addington v. Texas,93
Adolescents.
See also Children
binge eating, purging, and bulimia nervosa in,111–112
course of anorexia nervosa in,111
diagnosis of severe eating disorders in,109–110
family-based treatment for eating disorders,15, 114
parent–child relationship,114
rights and ability to refuse care,113–114
and transitional-age youth,114
treatment of anorexia nervosa in,44
treatment of eating disorders in,112–113
Alcoholism, parental,2
“Alpha-stim” devices,125
Americans with Disabilities Act,130
AN.
See Anorexia nervosa
Animal-assisted therapy, for SEEDs,130
Anorexia mirabilis, historical perspective of,3–4
Anorexia nervosa (AN).
See also Eating disorders; Severe and enduring anorexia nervosa; Severe and enduring eating disorders
binge-purge features of,12
bone mineral density loss in,xiv
characterization of,43, 168
clinical judgment vs. MacCAT-T,66–67
course of, in children and adolescents,111
description of,7
“end-stage”,166–168
historical perspective of,9–11
involuntary hospitalization for,2–43
mental capacity in,55–56, 65
morbidity and mortality associated with,xiii–xiv
as motivated behavioral disorder,43–44
nutrition and,xiv–xv
pharmacological interventions,120–122
phases of,140
recovery from,112–113
resistance to treatment,120
as syndrome of self-starvation,43
talk-based interventions,44
weight restoration in treatment of,44–45
Antidepressants, for anorexia nervosa,120
Antipsychotics, for anorexia nervosa,120
Anxiety, symptoms in children,2
ARFID.
See Avoidant/restrictive food intake disorder
Aristotle, ethics and,xvi
Armodafinil, for binge eating disorder,124
Armstrong, Paul W.,173, 175
Australiacivil commitment laws in,91
medical guardianship in,83
Western Australian Pregnancy Cohort (Raine) Study,112
Autonomy, description of,23
Avoidant/restrictive food intake disorder (ARFID), historical perspective of,4, 13–14
Ayahuasca, for bulimia nervosa,122–123
Baclofen, for bulimia nervosa,122
Balanchine, George,5–6
Baxter v. State,184
BED.
See Binge-eating disorder
Belgian Order of Medicine,182
Beneficence, description of,23
Benelux experience,182–183
Betsi Cadwaladr University Local Health Board vs. Miss W,177–178
Binge-eating disorder (BED)in children and adolescents,111–112
historical perspective of,12–13
pharmacological interventions for,123–124
Bipolar disorder,62
Bishop, Emmett,xviii
BN.
See Bulimia nervosa
Body mass index (BMI)fragility of,143
historical perspective of,5
Body shape, historical perspective of,5
Body weightgain rates,44–45
preoccupation with,4–6
restoration in treatment of anorexia nervosa,44–45
weight expectation reduction,141–142
Bone disease, medical consequence of eating disorders and,79
Bone mineral density,xiv
Brain.
See also Deep brain stimulation; Neurostimulation
anorexia nervosa and,9
cognitive functioning and,59
Brickman, Phillip,144
Brouwers, Aurelia,186–187
Brown, Helen Gurley,5
Bruch, Hilde,9–10
Bulimia nervosa (BN).
See also Eating disorders
in children and adolescents,111–112
historical perspective of,11–12
informal coercion of treatment for,46
monotherapy for,12
morbidity and mortality associated with,xiii–xiv
pharmacological interventions for,122–123
Pseudo-Bartter syndrome and,xv
Canadacivil commitment laws in,91
physician-assisted death in,184
Cannabis, for anorexia nervosa,121–122
Cannabis hyperemesis syndrome,122
Capacitydefinition of,81
description of,188
PAD and,188–189
palliative care evaluation,157–158
Cardiac disorders,76–77
Case lawAddington v. Texas,93
Baxter v. State,184
Betsi Cadwaladr University Local Health Board vs. Miss W,177–178
In the interest of D.C.W.,104–105
Local Authority vs. E and Others,175–177
In the Matter of A.G.,172–174
In the matter of Joanne Kolodrubetz,100–101
In the matter of Molly Kellor,101–102
In the Matter of S.A.,174–175
NHS Foundation Trust v. Ms. X,178
People of the State of Colorado in the interest of P.S.,103
People v. Medina,103
In re Judicial Commitment of W.R.,102
In re P.A.,103–104
In re S.A.M.,102–103
Category error, description of,169–170
Catholic Brothers of Charity,183
CBT.
See Cognitive-behavioral therapy
Centre County Court of Common Pleas,104–105
C-14 Medical Aid in Dying (MAID) law,184
Character, description of,26.
See also Narrative ethics
Children.
See also Adolescents
abuse in,2
anxiety symptoms in,2
binge eating, purging, and bulimia nervosa in,111–112
course of anorexia nervosa in,111
diagnosis of severe eating disorders in,109–110
family-based treatment for eating disorders,15, 114
medical child abuse,114–115
obsessive-compulsive personality traits in,2
treatment of eating disorders in,112–113
Chromium, for binge eating disorder,123
Chronicity, definition of,140
Civil commitment.
See also Hospitalization
beyond a reasonable doubt,93
clear and convincing evidence,93
education of attorneys and fact finders about severity of eating disorders,98–99
ethical principles of individuals with eating disorders,95–96
evidentiary standard,93
evolution of,89–90
frequency of individuals with eating disorders civilly committed,96
grave disability,92–93, 94
hospitalization à la demanded d’un tiers,90
hospitalization d’office,90
involuntary use of medications and special procedures,94–95
legal definition of “dangerousness,”94
“need for treatment” intervention,93
overview,89–90
patients’ outcome,97
patients’ perspective of,97–98
preponderance of the evidence,93
pros and cons in patients with eating disorders,96–97
reviews and appeals of,100
state laws and public perception of eating disorders,98
testimony of family members,99
in the United States,92–93
violation of due process and,102
Clinical ethics, description of,22
Clinical vignettesof autonomy vs. paternalism,160–162
of ethics,22–23, 29–30, 36–37
Coercioncontingency management interventions and,46
effect on treatment alliance,48–49
formal methods of,47–48
informal methods of,45–47
medical ethics and,42–43
objective,41–42
perceived,41–42, 81
in treatment,41–42
weight restoration in treatment of anorexia nervosa,44–45
Cognitionimpairments in,31
mental capacity and,65
of patients,30
somatic markers and,65
Cognitive-behavioral therapy (CBT)for anorexia nervosa,10
for SEED/SEAN,141
Cognitive remediation therapy, for SEEDs,129
Commonwealth of Nations, civil commitment laws in,91, 92
Community, obligations of,34–36
Competencedefinition of,55–56
as legal term,81
Confidentiality, limitations of,113–114
Consent,113–114, 173–174
Countertransference, palliative care and,159
Crisp, Arthur,9–10
CRPD.
See U.N. Convention on the Rights of Persons with Disabilities
Culture, influence on body weight,5–6
Cyclic vomiting syndrome,121–122
“Dangerousness,” legal definition of,94
DBS.
See Deep brain stimulation
Death with Dignity Act,184
Decisional capacity,28, 30–34
assessment of,31–32
Deep brain stimulation (DBS), for SEEDs,126.
See also Brain
Dehydroepiandrosterone, for anorexia nervosa,121
Delirium, palliative care and,158
Deontology, moral theories of,23–24
Dermatological disorders, with eating disorders,76
Disabilitydefinition of,84
grave,92–93
DSM-5, mental capacity in moderately ill patients and,64
Due process, violation of,102
Dutch Voluntary Euthanasia Society,183
Eating Disorder Examination score,58
Eating disorders (EDs).
See also Anorexia nervosa; Bulimia nervosa; Severe and enduring eating disorders
age of onset,16
assessment of mental capacity in patients with,59–62
cardiac manifestations,76–77
care provision,34–35
challenges in patients,65–68
civil commitment in,95–97
clinical outcomes and,33
decisional capacity in severe eating disorders,28, 30–34
diagnosis in children and adolescents,109–110
“disease staging,”16
education of attorneys and fact finders about severity of eating disorders,98–99
ethical decisional capacity in,30–34
evolution of treatment programs in,6–7
family-based treatment for children and adolescents,15
futility and,165–166, 168–170, 172–178
historical perspective of,1–6
“lumpers” and “splitters,”12
malnutrition and,14–15, 78
medical consequences of,76–80
bone disease,79
changes in head, ears, eyes, nose, and throat,76
dermatological changes,76
gastrointestinal complaints,77
hypoglycemia,79
hyponatremia,80
leukopenia,78
normocytic anemia,78
Pseudo-Bartter syndrome,80
pulmonary complications,77
refeeding syndrome,79–80
superior mesenteric artery syndrome,77–78
weakness and deconditioning,78–79
morbidity and mortality associated with,xiii–xv, 153
as motivated behavioral disorders,43–44
palliative care andadvance care planning,156–157
basic tenets of,154–155
capacity evaluation,157–158
choice of autonomy vs. paternalism,159–160
countertransference and,159
delirium,158
individual treatment,157
morbidity and mortality associated with,153
overview,153–154
psychiatrist as advocate,158–159
role of psychiatry in,154, 155–156
patient relapse,34
physician-assisted death,181–186
capacity and,188–189
ethics and,189–190
patient evaluation for,190–191
purging,78
state laws and public perception of eating disorders,98
treatmentin children and adolescents,112–113
early intervention,16
evidence-based parameters,14–16
family-based,15, 112–113
involuntary justifications for,28
medical ethics and coercive,42–43
medical guardianship for compulsory,75–84
nasogastric tube feeding,45, 47
relapse prevention,49
Eating Disorders Examination,141
Eating Recovery Center (ERC),xviii–xix
EBW.
See Expected body weight
ECT.
See Electroconvulsive therapy
EDs.
See Eating disorders
Ego-syntonic illness,140, 145
Electroconvulsive therapy (ECT)involuntary use of,94
for SEEDs,126–127
Elizabeth of Austria,5
End of Life Clinic,187
ERP.
See Exposure and response prevention therapy, for SEEDs
Ethics.
See also Case law
clinical vignette of,22–23, 29–30, 36–37
coercive treatment and medical,42–43
concurrent medical and psychiatric challenges of,26–30
decisional capacity in severe eating disorders,26–27, 28, 30–34
description of clinical,22
foundational principles in clinical,23–26
futility of eating disorders and,165–166
Hippocratic Oath,189, 191
physician-assisted death and,189–190
principles ofin civil commitment of individuals with eating disorders,95–96
in harm reduction,146–147
informed consent and,26–28
involuntary feeding,32–34
justifications for involuntary treatment,28
moral dilemmas in care of patients and,21–22
moral intuition and,23
narrative,25–26
obligations to community and licensing boards,34–36
origin of,xvi–xvii
overview,21–22
pluralism of theory of,26
principle-based approach to,24
requests for capacity evaluations,29
role in compelling treatment for patients with SEEDs,xvii
virtue,25
European Union, civil commitment laws in,90, 92
Euthanasia.
See Physician-assisted death
Expected body weight (EBW),141–142, 143
Exposure and response prevention (ERP) therapy, for SEEDs,129
Family.
See also Family-based treatment (FBT)
of patient,61
testimony in civil commitment,99
Family-based treatment (FBT)for children and adolescents,114, 129
for eating disorders,15, 112–113
Fasting,3–4
Feasting,2–3
Fisher Wallace stimulators,125
“Flapper” fashions,5
Fluoxetine, for bulimia nervosa,122
Futility, of eating disordersdecisional capacity to forgo life-sustaining treatment,170–171
definitions of,165–166, 174
“end-stage” anorexiacharacteristics of,168
existence of,166–168
history of,165–166
physiological,165
qualitative,166
quantitative,165–166
SEEDs and,168–170
Gastrointestinal disorders, with eating disorders,77
Gastroparesis, with eating disorders,77
Germany, civil commitment laws in,90–91
Ghrelin, for anorexia nervosa,121
“Gravely disabled” standard,94
Guardian.
See also Case law
description of,80
role of,81–82
Guardianship Act 1987,83–84
Gull, William,7, 10
Harm reduction.
See also Mental illness
accommodating distress in ego-syntonic illness,145
addiction psychiatry and,144
criteria for use of,146
description of,139–141,
142ethical issues and,146–147
ethical principles of,148
examples of approaches tooverview,141
purging symptoms reduction,142–143
weight expectation reduction,141–142
minimization of,139–140
model,xix, 139
outcome,147–148
parallels from other fields,143–145
patient testimonial about SEED/SEAN,148–150
rationale for approach to,145–146
support for,147
symptom acceptance versus endorsement,141
The Harvard Chan School of Public Health’s Strategic Training Initiative for the Prevention of Eating Disorders (STRIPED),35
Hefner, Hugh,6
Helicobacter pylori,7
Hepatitis, hypoglycemia and,82
Hillel,xvi, xvii
Hippocratic Oath,189, 191
Hormones, for anorexia nervosa,121
Hospice care,154, 158
Hospitalization, involuntary,42, 47, 90.
See also Civil commitment
Hypoglycemiamedical consequence of eating disorders and,79
starvation hepatitis and,82
Hyponatremia, medical consequence of eating disorders and,80
Illness.
See also Mental Illness
psychopathology of eating disorders and comorbid psychiatric conditions,15–16
sociocultural phenomena versus serious medical illnesses,1–2
In the interest of D.C.W.,104–105
In the Matter of A.G.,172–174
In the matter of Joanne Kolodrubetz,100–101
In the matter of Molly Kellor,101–102
In the Matter of S.A.,174–175
In re P.A.,103–104
In re S.A.M.,102–103
Incapacity, legal definition of,83
Informed consent,26–28
Institute of Medicine,27
Interviewingassessment of mental capacity,60–62
clinical interview versus quantitative assessment of mental capacity,62–65
motivational,49, 130
semistructured,62
Journal of Ethics in Mental Health,189
Justice, description of,24
Kashruth,4
Kennedy, Jacqueline,5
Ketamine, for anorexia nervosa,121
Kevorkian, Jack,190
Kim, Scott,189
Lagophthalmos,76
Lasègue, Charles,7, 10
Legal issues.
See also Medical guardianship
Benelux experience, with physician-assisted death,182–183
clinical judgment,170
due process, violation of,102
refusal of medical treatment,173–174
right to consent,113–114
use of coercion in treatment of psychiatric patients,42–43
LegislationAmericans with Disabilities Act,130
C-14 Medical Aid in Dying law,184
Death with Dignity Act,184
Guardianship Act 1987,83–84
Mental Health Act 2007,83
palliative care,156–157
Uniform Adult Guardianship and Protective Proceedings Jurisdiction Act,83
Lemmens, Willem,189
Leukopenia, with eating disorders,78
Liraglutide, for binge eating disorder,123
Lisdexamfetamine, for binge eating disorder,123
Local Authority vs. E and Others,175–177
MacArthur Competence Assessment Tool for Treatment (MacCAT-T)clinical interview vs. quantitative assessment,62–65
vs. clinical judgment,66–68
MacCAT-T.
See MacArthur Competence Assessment Tool for Treatment
Maher, John,189
MAID.
See C-14 Medical Aid in Dying law
Major depressive disorder,62
Malnutritionmedical consequences of eating disorders and,78
medical guardianship and,75
Maudsley Anorexia Nervosa Treatment for Adults,112–113, 129–130
Maurya, Chandragupta,3
McHugh, Paul,190
Medicaid, for eating disorder care,35
Medical guardianshipin Australia,83–84
medical consequences of severe eating disorders,76–80
overview,75
role of,80–82
in the United States,83
Medications.
See also individual drug names
involuntary use of,94
in palliative care,155
treatment standard,94–95
Memantine, for binge eating disorder,123
Mental capacityin anorexia nervosa, description of,55–56
assessment of,57–58
clinical judgment versus MacCAT-T,66–68
focus on cognitive factors,65
values and,65–66
individual characteristics,60–61
clinical interview vs. quantitative assessment,62–65
comorbidity psychiatric disorders and,61
decision-making,56–57
definition of,55–56
diminished,64, 68
effects of nutrition on,58–59
emergency status,61
family of patient,61
general principles of,56–57
incapacity,57
individual characteristics,60–61
moderately ill category according to DSM-5,64
motivation for treatment,61
patient appreciation and,66
patient’s medical situation,61
in patients with severe eating disorders,59–62
situational characteristics,61–62
stage of illness and,60–61
tests of,56
treatment history of patient,61–62
Mental Health Act 2007,83
Mental illness.
See also Harm reduction; Illness
stigma of,158–159
U.S. Supreme Court’s definition of,93
Mental incapacity,57
Microbiota, in treatment of SEEDs,130–131
Modelsof addiction psychiatry,144
of eating disorder care provision,34–35
harm reduction,xix, 139
Moral distress, definition of,28–29.
See also Narrative ethics
Moralityin care of patients,21–22
moral intuition,23
Morbidity and mortality,xiii–xiv, xv, 153.
See also Futility, of eating disorders; Physician-assisted death
Morton, Richard,7
Nalmefene, for treatment in binge eating disorder,123
Naltrexone monotherapy, for binge eating disorder,123
Narrative ethicsdescription of,25–26
primary elements in,25–26
Nasogastric tube feeding,45, 47
National Institute for Health and Care Excellence,12
Neuroendocrinologyof anorexia nervosa,8
treatment for patients with SEEDs, transcranial magnetic stimulation,124–125
Neurofeedbackdescription of,127
for SEEDs,127–128
Neurostimulation.
See also Brain
definition of,124
for SEEDs,124
NHS Foundation Trust v. Ms. X,178
N,N-dimethyltryptamine, for bulimia nervosa,122
Nonmaleficence, description of,23
Normocytic anemia, medical consequences of eating disorders and,78
Nutritionanorexia nervosa and,xiv–xv
effects on mental capacity,58–59
feeding and dietary interventions for SEEDs,130–131
involuntary feeding,32–34
preoccupation with food,58
reversing nutritional insufficiencies,14–15
Objective coercion,41–42
Orthorexia,131
Oxytocinfor anorexia nervosa,121
for binge eating disorder,123
PAD.
See Physician-assisted death
Palliation.
See Palliative care
Palliative care,xix
advance care planning,156–157
basic tenets of,154–155
capacity evaluation,157–158
definition of,154–155
futility of eating disorders and,172
individual treatment,157
overview,153–154
recovery and,154, 155
role of psychiatry in,154, 155–156
Parentsalcoholism in,2
parent–child relationship,114
Pari passu,8
Paternalism, definition of,27.
See also Narrative ethics
Patient-centered care, definition of,27
Patients.
See also Practitioner
ability to make choices,56–57
assessment of mental capacity in,59–62, 65–68
autonomy of,158–160
capacity evaluations of,29
cognition in,30, 31
decisional capacity in,28, 30–34, 55, 170–171
dermatological changes in,76
evaluation for physician-assisted death,190–191
involuntary feeding,32–34
medical situation of,61
moral and ethical dilemmas in care of,21–22
next of kin,31
outcome in civil commitment,97
patient-centered care,27
perceptions of coercive treatment,41–42
perspective of civil commitment,97–98
quality of life in,27, 36, 37
relapse of eating disorders,34
testimonial about SEED/SEAN,148–150
therapeutic alliances with practitioner,33
weakness and deconditioning,78–79
PBS.
See Pseudo-Bartter syndrome
People v. Medina,103
People of the State of Colorado in the interest of P.S.,103
Perceived coercion,41–42
guardianship and,81
Percent of ideal body weight (%IBW),xiv
Personality, obsessive-compulsive personality traits in,2
Phentermine, for binge eating disorder,123
Physician-assisted death (PAD)Benelux experience,182–183
Canadian experience,184
capacity and,188–189
case of Ann G.,186
description of,181–182
ethics and,189–190
euthanasia and,185
examples of,186–188
legalization of,184–186
patient evaluation for,190–191
U.S. experience,184–186
Physician’s Orders for Life-Sustaining Treatment (POLST),172
Physiological futility, description of,165
Pima Indians,3
Plot, description of,26.
See also Narrative ethics
POLST.
See Physician’s Orders for Life-Sustaining Treatment
Pothoven, Noa,187
Practitioner.
See also Patients
therapeutic alliances, with coercion,48–49
therapeutic alliances with patient,33
virtue ethics approach to patient care,25
Pseudo-Bartter syndrome (PBS)bulimia nervosa and,xv
medical consequence of eating disorders and,80
Psychiatristas advocate in palliative care,158–159
role in physician-assisted death,190
Psychiatryharm reduction and,144
role of psychiatry in palliative care of SEEDs,155–156
Psychotherapy, novel, for SEEDs,128–130
Pulmonary disorders, with eating disorders,77
Purgingin children and adolescents,111–112
medical consequences of eating disorders and,78
symptoms reduction,142–143
Qualitative futility, description of,166
Quality of lifefragility of BMI and,143
low,37
in patient-centered care,27
patient limitations and,36
of SEED patients,112
treatment of SEEDs and,120
Quantitative futility, description of,165–166
Randomized controlled trial (RCT), for anorexia nervosa,xiv
Refeeding syndrome, medical consequence of eating disorders and,79–80
Relapse, prevention of,49
Repetitive transcranial magnetic stimulation (rTMS), for SEEDs,124–125
Resolution, description of,26.
See also Narrative ethics
Rituals, food-related,4
Roman Catholic Church,4
rTMS.
See Repetitive transcranial magnetic stimulation (rTMS), for SEEDs
Russell, Gerald,9–10, 11
Sallekhana,3
Schizophrenia,62–63
SEAN.
See Severe and enduring anorexia nervosa
SEEDs.
See Severe and enduring eating disorders
Severe and enduring anorexia nervosa (SEAN),140.
See also Anorexia nervosa
Severe and enduring eating disorders (SEEDs).
See also Anorexia nervosa; Eating disorders
age criteria of,110
animal therapy for,130
challenges in treatment ofconstruction of specialized facilities,xviii
involuntary treatment,xviii–xix
resource allocation,xvii–xviii
in children and adolescents,109–115
definition of,109–110
feeding and dietary interventions for,130–131
futility and,168–170
neurofeedback for,127–128
neurostimulation,124
deep brain stimulation,126
electroconvulsive therapy,126–127
transcranial magnetic stimulation,124–125
novel psychotherapies for,128–130
overview,119–120
patient’s testimonial about,148–150
pharmacological interventionsfor anorexia nervosa, restricting type,120–122
for binge eating disorder,123–124
for bulimia nervosa,122–123
quality of life with,112, 120
role of ethics in compelling treatment for patients with,xvii
role of psychiatry in palliative care of,155–156
virtual reality therapy,128
Sibutramine, for binge eating disorder,123
SMA.
See Superior mesenteric artery syndrome
Sodium oxybate, for binge eating disorder,123
Somatic markers, cognition and,65
Starvationeffects of nutrition on mental capacity,58–59
as motivated behavioral disorder,43
Steinsaltz, Adin,xvi
STRIPED.
See The Harvard Chan School of Public Health’s Strategic Training Initiative for the Prevention of Eating Disorders
Suicide.
See Physician-assisted death
Superior mesenteric artery syndrome (SMA)with eating disorders,77–78
morbidity and mortality associated with,xiv
Taboos, food-related,4
Kashruth,4
tDCS.
See Transcranial direct current stimulation, for SEEDs
Terminal illness.
See Futility, of eating disorders; Physician-assisted death
Therapeutic alliance,33
coercion and effect on,48–49
psychiatrist as advocate in palliative care,158–159
Thienpont, Lieve,183
“Tight-wasting,”5
Topiramate, for binge eating disorder,123
Transcranial direct current stimulation (tDCS), for SEEDs,125
Transcranial magnetic stimulation (TMS), for SEEDs,124–125
Transcranial Magnetic Stimulation and Neuroimaging in Anorexia Nervosa study,124–125
Transdermal estradiol, for anorexia nervosa,121
Tyrosine, for anorexia nervosa,121
UAGPPJA.
See Uniform Adult Guardianship and Protective Proceedings Jurisdiction Act
U.N. Convention on the Rights of Persons with Disabilities (CRPD),92
“Underfeeding,”xv
Uniform Adult Guardianship and Protective Proceedings Jurisdiction Act (UAGPPJA),83
United Kingdom, civil commitment laws in,91
United States.
See also Civil commitment
civil commitment in,92–93
medical guardianship in,83
Physician-assisted death in,184–186
Supreme Court’s definition of mental illness,93
Uniting Couples (in the treatment of) Anorexia Nervosa,129
Utilitarianism, moral theories of,23–24
“Venus of Willendorf,”2–3
Virtual reality therapy,128
Virtues, definition of,24–25
Voice, description of,26.
See also Narrative ethics
“Weight disruption,”xv
Weiner, Ken,xviii
Weismann Social Adjustment Scale,141
West, Ellen,8
Western Australian Pregnancy Cohort (Raine) Study,112