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Abstract

Bipolar disorder is associated with cognitive deficits, which persist across mood states and affect functional outcomes. This article provides an overview of recent progress in measuring cognition in bipolar disorder and its implications for both research and clinical practice. The authors summarize work conducted over the past decade that has helped guide researchers and clinicians in the appropriate measurement of cognitive functioning in bipolar disorder, the design of research studies targeting this domain for treatment, and the implementation of screening and psychoeducational tools in the clinic. Much of this work was conducted by the International Society for Bipolar Disorders Targeting Cognition Task Force. Here, the authors also highlight the need for clinicians to be informed about this aspect of illness and to be equipped with the necessary information to assess, track, and intervene on cognitive problems when appropriate. Finally, the article identifies gaps in the literature and suggests potential future directions for research in this area.

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Published In

History

Published in print: Fall 2023
Published online: 16 October 2023

Keywords

  1. Bipolar and Related Disorders
  2. Cognition/Learning/Memory
  3. Guidelines
  4. Quality of life

Authors

Affiliations

Jennifer Nicoloro-SantaBarbara, Ph.D.
Department of Psychiatry, Brigham and Women’s Hospital, Boston (Nicoloro-SantaBarbara, Majd, Burns, Burdick); Harvard Medical School, Boston (Nicoloro-SantaBarbara, Majd, Burdick); Department of Psychology, University of Copenhagen, and Mental Health Services, Capital Region of Denmark, Copenhagen (Miskowiak); Centre for Addiction and Mental Health, Toronto (Goldstein); and Department of Psychiatry and Department of Pharmacology, University of Toronto, Toronto (Goldstein).
Marzieh Majd, Ph.D., Pharm.D.
Department of Psychiatry, Brigham and Women’s Hospital, Boston (Nicoloro-SantaBarbara, Majd, Burns, Burdick); Harvard Medical School, Boston (Nicoloro-SantaBarbara, Majd, Burdick); Department of Psychology, University of Copenhagen, and Mental Health Services, Capital Region of Denmark, Copenhagen (Miskowiak); Centre for Addiction and Mental Health, Toronto (Goldstein); and Department of Psychiatry and Department of Pharmacology, University of Toronto, Toronto (Goldstein).
Kamilla Miskowiak, Ph.D.
Department of Psychiatry, Brigham and Women’s Hospital, Boston (Nicoloro-SantaBarbara, Majd, Burns, Burdick); Harvard Medical School, Boston (Nicoloro-SantaBarbara, Majd, Burdick); Department of Psychology, University of Copenhagen, and Mental Health Services, Capital Region of Denmark, Copenhagen (Miskowiak); Centre for Addiction and Mental Health, Toronto (Goldstein); and Department of Psychiatry and Department of Pharmacology, University of Toronto, Toronto (Goldstein).
Katharine Burns, B.A.
Department of Psychiatry, Brigham and Women’s Hospital, Boston (Nicoloro-SantaBarbara, Majd, Burns, Burdick); Harvard Medical School, Boston (Nicoloro-SantaBarbara, Majd, Burdick); Department of Psychology, University of Copenhagen, and Mental Health Services, Capital Region of Denmark, Copenhagen (Miskowiak); Centre for Addiction and Mental Health, Toronto (Goldstein); and Department of Psychiatry and Department of Pharmacology, University of Toronto, Toronto (Goldstein).
Benjamin I. Goldstein, M.D., Ph.D.
Department of Psychiatry, Brigham and Women’s Hospital, Boston (Nicoloro-SantaBarbara, Majd, Burns, Burdick); Harvard Medical School, Boston (Nicoloro-SantaBarbara, Majd, Burdick); Department of Psychology, University of Copenhagen, and Mental Health Services, Capital Region of Denmark, Copenhagen (Miskowiak); Centre for Addiction and Mental Health, Toronto (Goldstein); and Department of Psychiatry and Department of Pharmacology, University of Toronto, Toronto (Goldstein).
Katherine E. Burdick, Ph.D. [email protected]
Department of Psychiatry, Brigham and Women’s Hospital, Boston (Nicoloro-SantaBarbara, Majd, Burns, Burdick); Harvard Medical School, Boston (Nicoloro-SantaBarbara, Majd, Burdick); Department of Psychology, University of Copenhagen, and Mental Health Services, Capital Region of Denmark, Copenhagen (Miskowiak); Centre for Addiction and Mental Health, Toronto (Goldstein); and Department of Psychiatry and Department of Pharmacology, University of Toronto, Toronto (Goldstein).

Notes

Send correspondence to Dr. Burdick ([email protected]).

Author Contributions

Dr. Nicoloro-SantaBarbara and Dr. Majd are co-first authors.

Competing Interests

Dr. Burdick reports receiving an honorarium from Breakthrough Discoveries for Thriving with Bipolar Disorder (BD2) for her role as Scientific Director for the Integrated Network. Dr. Nicoloro-SantaBarbara reports receiving consulting fees from Cogent Biosciences. Dr. Miskowiak reports receiving consultancy fees for her advisory work for Gedeon Richter, Janssen, Angelini Pharma, and Lundbeck. Dr. Goldstein acknowledges his position as RBC Investments Chair in Children’s Mental Health and Developmental Psychopathology at The Centre for Addiction and Mental Health (CAMH), a joint Hospital-University Chair between the University of Toronto, CAMH, and the CAMH Foundation. The other authors report no financial relationships with commercial interests.

Funding Information

This work was supported in part by NIMH grant R01 MH124381 (to Dr. Burdick).

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