No access
Clinical and Research Reports
Published Online: 12 February 2024

From Software to Hardware: A Case Series of Functional Neurological Symptoms and Cerebrovascular Disease

Jan Coebergh, M.B.B.S., F.R.C.P. [email protected], Shabana Habib, M.B.B.S., Tiago Teodoro, M.B.B.S., Ph.D., Mark Edwards, M.B.B.S., Ph.D., and Matt Butler, M.B.B.S.Authors Info & Affiliations
Publication: The Journal of Neuropsychiatry and Clinical Neurosciences
Volume 36, Number 3
https://doi.org/10.1176/appi.neuropsych.20220182
Track CitationsAdd to favorites
Get Access

Abstract

Objective:

Neuroimaging studies have identified alterations in both brain structure and functional connectivity in patients with functional neurological disorder (FND). For many patients, FND emerges from physical precipitating events. Nevertheless, there are a limited number of case series in the literature that describe the clinical presentation and neuroimaging correlates of FND following cerebrovascular disease.

Methods:

The authors collected data from two clinics in the United Kingdom on 14 cases of acute, improving, or delayed functional neurological symptoms following cerebrovascular events.

Results:

Most patients had functional neurological symptoms that were localized to cerebrovascular lesions, and the lesions mapped onto regions known to be part of functional networks disrupted in FND, including the thalamus, anterior cingulate gyrus, insula, and temporoparietal junction.

Conclusions:

The findings demonstrate that structural lesions can lead to FND symptoms, possibly explained through changes in relevant mechanistic functional networks.

Get full access to this article

View all available purchase options and get full access to this article.

Get Access

Information & Authors

Information

Published In

Go to The Journal of Neuropsychiatry and Clinical Neurosciences
Go to The Journal of Neuropsychiatry and Clinical Neurosciences
The Journal of Neuropsychiatry and Clinical Neurosciences
Volume 36 • Number 3 • Summer 2024
Pages: 206 - 213
PubMed: 38343312

History

Received: 14 October 2022
Revision received: 25 February 2023
Revision received: 7 May 2023
Revision received: 4 July 2023
Revision received: 18 September 2023
Accepted: 19 October 2023
Published online: 12 February 2024
Published in print: Summer 2024

Keywords

  1. Cerebrovascular Disease
  2. Hoover’s Sign
  3. Functional Neurological Disorder
  4. Functional Symptoms
  5. Stroke
  6. Structure-Function Relationship

Authors

Details

Jan Coebergh, M.B.B.S., F.R.C.P. [email protected]
St. George’s University Hospitals National Health Service Foundation Trust, London (Coebergh, Teodoro); Department of Neurology, Ashford and St. Peter’s Hospitals National Health Service Foundation Trust, Chertsey, United Kingdom (Coebergh, Teodoro); St. John’s Institute of Dermatology, London (Habib); Institute of Psychiatry, Psychology, and Neuroscience, King’s College London (Edwards, Butler).
View all articles by this author
Shabana Habib, M.B.B.S.
St. George’s University Hospitals National Health Service Foundation Trust, London (Coebergh, Teodoro); Department of Neurology, Ashford and St. Peter’s Hospitals National Health Service Foundation Trust, Chertsey, United Kingdom (Coebergh, Teodoro); St. John’s Institute of Dermatology, London (Habib); Institute of Psychiatry, Psychology, and Neuroscience, King’s College London (Edwards, Butler).
View all articles by this author
Tiago Teodoro, M.B.B.S., Ph.D.
St. George’s University Hospitals National Health Service Foundation Trust, London (Coebergh, Teodoro); Department of Neurology, Ashford and St. Peter’s Hospitals National Health Service Foundation Trust, Chertsey, United Kingdom (Coebergh, Teodoro); St. John’s Institute of Dermatology, London (Habib); Institute of Psychiatry, Psychology, and Neuroscience, King’s College London (Edwards, Butler).
View all articles by this author
Mark Edwards, M.B.B.S., Ph.D.
St. George’s University Hospitals National Health Service Foundation Trust, London (Coebergh, Teodoro); Department of Neurology, Ashford and St. Peter’s Hospitals National Health Service Foundation Trust, Chertsey, United Kingdom (Coebergh, Teodoro); St. John’s Institute of Dermatology, London (Habib); Institute of Psychiatry, Psychology, and Neuroscience, King’s College London (Edwards, Butler).
View all articles by this author
Matt Butler, M.B.B.S.
St. George’s University Hospitals National Health Service Foundation Trust, London (Coebergh, Teodoro); Department of Neurology, Ashford and St. Peter’s Hospitals National Health Service Foundation Trust, Chertsey, United Kingdom (Coebergh, Teodoro); St. John’s Institute of Dermatology, London (Habib); Institute of Psychiatry, Psychology, and Neuroscience, King’s College London (Edwards, Butler).
View all articles by this author

Notes

Send correspondence to Dr. Coebergh ([email protected]).

Competing Interests

Dr. Coebergh has received remuneration from Bial, Brittania, and Janssen for educational events. Dr. Edwards provides medical expert reporting in personal injury and clinical negligence cases; he owns shares in Brain and Mind and has received financial support for lectures from the International Parkinson’s and Movement Disorders Society and the Functional Neurological Disorder Society (FNDS), royalties from Oxford University Press, and honoraria for medical advice to Teva Pharmaceuticals; and he is an associate editor of the European Journal of Neurology, a member of the international executive committee of the International Parkinson’s and Movement Disorders Society, a board member of the FNDS, and a medical advisory board member of the FND Hope UK and Dystonia UK charities. The other authors report no financial relationships with commercial interests.

Metrics & Citations

Metrics

Citations

Export Citations

If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download.

For more information or tips please see 'Downloading to a citation manager' in the Help menu.

Format
Citation style
Style
Copy to clipboard
Tips for downloading citations

View Options

Get Access

Login options

Already a subscriber? Access your subscription through your login credentials or your institution for full access to this article.

Personal login Institutional Login Open Athens login
Item saved, go to cart
Purchase Options

Purchase this article to access the full text.

PPV Articles - Journal of Neuropsychiatry and Clinical Neurosciences

PPV Articles - Journal of Neuropsychiatry and Clinical Neurosciences

Not a subscriber?

Subscribe Now / Learn More

PsychiatryOnline subscription options offer access to the DSM-5-TR® library, books, journals, CME, and patient resources. This all-in-one virtual library provides psychiatrists and mental health professionals with key resources for diagnosis, treatment, research, and professional development.

Need more help? PsychiatryOnline Customer Service may be reached by emailing [email protected] or by calling 800-368-5777 (in the U.S.) or 703-907-7322 (outside the U.S.).

View options

PDF/EPUB

View PDF/EPUB

Full Text

View Full Text

Media

Figures

Other

Tables

Share

Share

Share article link

Share

×

As described within the American Psychiatric Association (APA)'s Privacy Policy and Terms of Use, this website utilizes cookies, including for the purpose of offering an optimal online experience and services tailored to your preferences. Please read the entire Privacy Policy and Terms of Use. By closing this message, browsing this website, continuing the navigation, or otherwise continuing to use the APA's websites, you confirm that you understand and accept the terms of the Privacy Policy and Terms of Use, including the utilization of cookies.