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Published Online: 30 June 2017

NIH Partners With Industry to Stem Opioid Crisis

Data from the Centers for Disease Control and Prevention suggest that more than 90 Americans die every day from opioid overdoses, an epidemic that seems to be becoming only more entrenched. To get in front of this public health crisis, the National Institutes of Health (NIH) is teaming up with the pharmaceutical industry in a three-pronged research initiative.
“Recent NIH-industry partnerships, such as the Accelerating Medicines Partnership, demonstrate the power of public–private collaboration in speeding the development of new medications,” wrote NIH Director Francis Collins, M.D., Ph.D., and National Institute on Drug Abuse Director Nora Volkow, M.D., in a special report published May 31 in the New England Journal of Medicine. “Ending the opioid crisis will require this kind of collaboration.”
This new public-private partnership will include short-, intermediate-, and long-term research strategies aimed at developing better opioid overdose-reversal interventions, finding new medications and technologies to treat opioid addiction, and developing nonaddictive therapies for chronic pain. In addition, a goal that cuts across all three focus areas is to reduce the time typically required to develop new safe and effective therapeutics by half.
In the article, Collins and Volkow highlighted existing drugs developed through such partnerships, including Probuphine, a long-lasting buprenorphine implant recently approved by the FDA, and Narcan nasal spray.
But while pharmacology will be front and center, Collins and Volkow stated that other clinical avenues will be pursued as well. These include brain-stimulation technologies such as repetitive transcranial magnetic stimulation, gene therapies that deliver anti-inflammatory proteins directly to sites of pain, and even opioid-targeted vaccines to keep these drugs out of the brain.
“The Role of Science in Addressing the Opioid Crisis” can be accessed here.

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Published online: 30 June 2017
Published in print: June 17, 2017 – July 7, 2017

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  1. opioid overdoses

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