Hundreds of controlled studies have examined the effects of therapeutic interventions for psychiatric disorders among children and adolescents and have found a moderate impact of these interventions on these disorders (
1). Such research studies are typically conducted in resource-rich settings characterized by rigorous training of therapists, monitoring of fidelity to treatment protocol, and inclusion criteria limiting comorbid conditions. However, usual care takes place in a variety of settings, involves a variety of assessments, and is provided by professionals with varying educational backgrounds and degrees of training. In addition, presence of comorbid conditions is the norm, and the therapy may or may not be manualized and is typically not closely monitored (
2). For policy makers, health care planners, service providers, parents, and patients alike, the question is whether such usual care reduces the prevalence of mental health problems and associated impairments. To answer this question, one cannot rely on generalizing from controlled studies of specific therapies for a narrow set of disorders. Ethical and legislative regulations prohibit assigning help-seeking children to a no-treatment or a waitlist condition. Instead, studies with observational designs that limit the impact of confounding must be performed. To address the paucity of such studies, the aim of this study was to use novel analytical techniques in order to investigate whether usual care for mental health problems is significantly associated with beneficial mental health outcomes among young children.
Few longitudinal studies have examined how children receiving usual care for mental health problems fare compared with children who do not receive such care. We identified three prospective cohort studies with community samples that fit this description. The major obstacle to drawing causal conclusions from observational studies is that such studies typically do not control for factors influencing both service use and mental health. In the first study, Zwaanswijk and colleagues (
3) found that service use or any control variables (i.e., gender, age, parents’ education, and contact with general practitioners) were not significantly associated with any changes in mental health problems. Applying a covariate approach and adjusting analyses for initial symptom level and previous symptom change, Angold and colleagues (
4) reported that usual care in specialty child and adolescent mental health services (CAMHS) had a positive effect on psychiatric symptoms. Because a range of factors beyond severity of symptoms lead to initiation of service use (
5,
6), these findings may be attributable to unmeasured confounders, as the authors acknowledge. Jörg et al. (
7) applied propensity score matching in which a quasi-experimental design was constructed by creating a control group as similar as possible to the treatment group in terms of the measured characteristics. The authors found that the mental health of children who used services improved less than the mental health of those who did not use services. Importantly, although propensity score matching may be advantageous to a traditional covariate approach, the results of such matching approach still are based on measured confounders and unmeasured confounders cannot be ruled out.
Within-person approaches (
8) can be used to adjust for one type of unmeasured confounding, that is, factors that do not vary over time (e.g., stable impacts of genes or personality or stable attitudes toward the health care system). However, results from within-person approaches can still be influenced by time-varying confounders. We combined within-person analysis with propensity scoring to adjust for measured time-varying confounders and all unmeasured time-invariant confounders.
Beyond a reduction in symptoms, a common aim of service provision is to alleviate impairment due to mental health problems. Moreover, for children and adolescents to be functional—in terms of interactions with peers and family and participation in school—social skills are beneficial, and improved social skills can also be considered a desired outcome of interventions.
Following up with a community sample of children ages 4–14 years biennially, we examined whether receiving usual care in early and middle childhood predicts changes in symptoms of psychiatric disorders, associated impairments, and social skills, after adjustment for all unmeasured time-invariant and measured time-varying confounders. We hypothesized that receiving usual care would be associated with greater improvements in these conditions, compared with not receiving usual care.
Methods
Study Design
This study utilized data from the Trondheim Early Secure Study (
9), a prospective longitudinal cohort study focusing on children’s psychosocial development, following up two birth cohorts with biennial assessments. Data were collected in 2-year increments at six time points (T) (i.e., T1, 2007–2009; T2, 2009–2011; T3, 2011–2013; T4, 2013–2015; T5, 2015–2017, and T6, 2017–2019).
Participants
Children and parents from the 2003 and 2004 birth cohorts in the city of Trondheim, Norway, were invited to participate in the study during routine health checkups for 4-year-olds at local well-child clinics. Of the 3,013 families with sufficient Norwegian language skills (N=176 were excluded because of a lack of language skills), 2,475 consented to participate. Participants were stratified into four groups on the basis of scores on the Strengths and Difficulties Questionnaire (SDQ), version 4–16 years, completed by parents (cutoff scores: 0–4, 5–8, 9–11, and 12–14, with higher scores indicating more severe mental health problems) (
10). Children with higher SDQ scores were oversampled to increase the number of participants in the sample with mental health problems (drawing probabilities, indicating likelihood of being drawn for further participation, by stratum: 0.37, 0.48, 0.70, and 0.89, respectively), and 1,250 were invited to participate in the first examination (T1) at 4 years of age. We obtained diagnostic and service use information from 80% (N=996 of 1,250) of consenting participants (mean±SD age=4.5±0.3 years) at T1. Follow-ups were performed after 2 years (T2: mean age=6.7±0.2, N=752), 4 years (T3: mean age=8.8±0.2, N=670), 6 years (T4: mean age=10.5±0.2, N=678), 8 years (T5: mean age=12.5±0.7, N=638), and 10 years (T6: mean age=14.4±0.2, N=628). Lower social skills at T1 and T4 predicted attrition at T2 and T5, respectively (T2: OR=1.02, 95% CI=1.00–1.03; T5: OR=1.05, 95% CI=1.02–1.07), and lower socioeconomic status at T4 predicted attrition at T5 (OR=1.38, 95% CI=1.02–1.88). A higher propensity for service use at T2 predicted reduced attrition at T3 (OR=0.54, 95% CI=0.31–0.96). According to Cox-Snell R
2 values, the predictors at T1 accounted for 2% of the attrition between T1 and T2, and T3 and T4 predictors accounted for 2% and 4%, respectively, indicating that it was unlikely that selective attrition had influenced results. The Regional Committee for Medical and Health Research Ethics, Mid-Norway, approved the study.
Norwegian Health Care System
In Norway, health services for those <18 years are provided for free. Services are divided into CAMHS and community services (e.g., social services, well-child clinics, general practitioners, child protection services, community psychologists, and school health nurses). Information about the number of children utilizing these various community services was not available. Data for CAMHS reveal that in 2018, the health region that covers the city of Trondheim served 8,330 children (5.4% of the population) ages 0–18, of whom 52.2% were boys and 44.8% were <12 years old (
11).
Measures
Service use.
Parents were interviewed at T1–T6 with the Child and Adolescent Service Assessment (CASA) (
12). The CASA identifies help provided for psychiatric problems. Service use is defined as efforts to identify, diagnose, or manage behavioral, emotional, or substance-related problems. At T1, the interview captured service use from birth until age 4, and at T2–T6, service use after the previous visit. A binary variable reflecting service use in the previous 2 years (4 years at T1) was created at each time point. A child could have received more than one service within one period.
Symptoms of psychiatric disorders.
The Preschool Age Psychiatric Assessment (PAPA) (
13) was completed by the parents at T1–T2. The PAPA is a semistructured, interviewer-based tool designed to obtain information about psychiatric disorders in young children defined according to the
DSM-IV (
14). Information about the frequency, intensity, duration, and onset of each symptom is recorded. At T3–T6, the Child and Adolescent Psychiatric Assessment (CAPA) (
15) was administered separately to children and parents. A symptom was considered present if it was reported by the child or the parent. For attention-deficit hyperactivity disorder (ADHD), only parent-reported symptoms were recorded (
15). Symptoms of behavioral disorders (i.e., oppositional defiant disorder, conduct disorder, and ADHD) and emotional disorders (i.e., major depression, dysthymia, depression not otherwise specified, separation anxiety disorder, generalized anxiety disorder, social phobia, specific phobia, agoraphobia, selective mutism, and obsessive-compulsive disorder) were summed at each time point. The PAPA and CAPA apply a 3-month primary period. The developers of the PAPA and the CAPA trained the interviewers. Raters who were blind to conditions recoded 9% of the PAPA (intraclass coefficient [ICC]=0.96) and 15% of the CAPA interviews (T3 and T4, ICC=0.94).
Impairment.
The PAPA and CAPA also record the presence of impairment in the past 3 months related to the reported symptoms in 19 different areas of functioning (e.g., relationships with parents, school function, and play) on the basis of the World Health Organization’s International Classification of Functioning, Disability and Health (
16). The number of areas with impaired functioning was summed.
Social skills.
Teacher-reported social skills were obtained by using the Social Skills Rating Systems (SSRS-T) preschool (T1) and school (T2–T6) versions (
17). The SSRS-T includes a set of statements covering three domains—cooperation, assertion, and self-control—and responses are recorded by using the following scale: 1, never; 2, sometimes; 3, often; and 4, very often. Each domain includes 10 statements, allowing a maximum score of 120, with higher scores indicating higher levels of social skills. Scores from each domain were summed (Cronbach’s α=0.93–0.94).
Confounders.
Variables entered into the propensity score for service use were based on previous work regarding predictors of referral (
5,
18–
20). These included a child having a
DSM-IV–defined emotional or behavioral disorder. In addition, all diagnoses were summed to create a continuous variable reflecting the extent of comorbid conditions. Parents’ perceived need for help was recorded with the PAPA and CAPA and was coded 0, no, or 1, yes. A binary variable for previous service use was created by using information from the CASA. The summed score on the general functioning subscale of the McMaster Family Assessment Device (Cronbach’s α=0.87–0.90) was included as a measure of family functioning (
21). Occupational status, as reported by the parent and coded according to the International Labour Organization’s scheme for classifying occupations (
22), was used as a measure of socioeconomic status. Parental mental health was measured with summed scores of the Beck Depression Inventory (
23), Beck Anxiety Inventory (
24) (T1–T2), and Hopkins Symptom Checklist–25 (
25) (T3–T6). Finally, living with a biological parent was included as a variable.
Statistical Analysis
Propensity score modeling.
Propensity score modeling was used to control for observed initial differences between children who received treatment and those who did not. We used binary logistic regression to determine the propensity for service use at each time point. The log of the odds of the probability of exposure was used as the propensity score (
26). To avoid including variables whose variation could be affected by usual care (for which we were determining the propensity), the score for T1 included only living with biological parents and socioeconomic status.
Random intercept, cross-lagged panel model (RI-CLPM).
Propensity scores were entered into an RI-CLPM by using Mplus, version 8.1 (
27), applying a maximum likelihood estimator with robust standard errors. Missing data were handled in accordance with a full maximum-likelihood procedure. Because of oversampling, population weights were applied to obtain correct population estimates. The RI-CLPM is a structural equation model in which each observed score is decomposed into a within-person part and a between-person part by including random intercepts in a CLPM, removing stable between-person components, and effectively controlling for all time-invariant confounders (
8). In turn, the within-person, time-varying components are used to estimate cross-lagged and autoregressive paths. (A simplified model is provided in the
online supplement to this article.) To avoid negative degrees of freedom, our outcomes (i.e., symptoms, impairment, and social skills) were estimated in separate models. Service use, propensity score, and outcome were included at all six time points.
Results
A similar number of boys and girls participated in the study (
Table 1). The prevalence of service use for mental health problems increased substantially, from 4% (N=44 of 996) at T1 to 18% (N=137 of 752) at T2, and remained at that level throughout childhood and early adolescence (T3: 17%, N=111 of 670; T4: 19%, N=127 of 678; T5: 17%, N=106 of 638; and T6: 18%, N=113 of 628). Characteristics of service use are provided in
Table 2. Most children did not receive any services at each time point (T1: 96%, N=952; T2: 82%, N=615 of 752; T3: 83%, N=559 of 670; T4: 81%, N=551 of 678; T5: 83%, N=532 of 638; and T6: 82%, N=515 of 628). Among children <8 years, health nurses were the most commonly reported helpers. Older children were most frequently seen by a psychologist. Although the number of treatment sequences remained stable across all time points, the mean number of treatment sessions varied greatly. Few children had received psychotropic medications, and most of the psychotropic medication treatments were for ADHD (stimulants and nonstimulants). (A table with descriptive statistics of the study variables is available in the
online supplement.) As expected, children who received services had higher log odds of receiving services at all time points (see the
online supplement).
Table 3 shows the results of the RI-CLPM with added propensity scores, with controls for all time-invariant and measured time-varying confounders. Usual care received in the past 2 years did not predict changes in impairment due to mental health problems or social skills. Similarly, we did not find changes in psychiatric symptoms associated with previous service use among 7- to 14-year-olds. Receiving usual care in early childhood (ages 0–4 years) and in late preschool (ages 5–6) predicted an increase in the number of psychiatric symptoms 2 years later.
Discussion
We investigated whether receiving usual care for mental health problems at ages 0–12 years predicted changes in the number of symptoms, impairments, and social skills 2 years following care receipt, after adjustment for the propensity of using services and all unmeasured time-invariant confounders. Receiving usual care was not associated with a decreasing number of psychiatric symptoms, reduced impairment, or better social skills among the children included in this study. In contrast, receiving usual care for mental health issues at ages 0–6 years predicted a slight increase in psychiatric symptoms 2 years later, compared with children who did not receive any services.
We note that heterogeneity may have been present in the results with respect to the content and duration of services, where services were provided, the type of service provider (e.g., psychiatrist, psychologist, or nurse), or nature of the child’s mental health problems, among other factors. If some children benefited from services, the observed lack of an effect of services on children’s mental health may be explained by any positive outcomes having been offset by negative effects of the services. It is also possible that receiving usual care did not alter vital outcomes for most children or that any changes that did occur were too modest to be detected in this study. Our results contradict the findings of Jörg and colleagues (
7), who concluded that service provision during preadolescence predicted an increase in symptoms, and those of Angold and colleagues (
4), who found that service provision reduced symptoms. Neither of these studies adjusted their analyses for time-invariant confounders, and the study by Angold and colleagues adjusted analyses only for the initial values of the outcome. Although we adjusted for confounders in our analyses, in the absence of randomization, unmeasured time-varying confounders (e.g., time-varying parenting practices) could still have influenced the results.
The CASA definition of service provision included not only treatment but also screening for and diagnosis of mental health. Furthermore, significant heterogeneity existed in the types of services. Distinguishing between different types of services and content would have enabled a more precise analysis. Such more detailed analysis was not possible because a further division of our sample into subgroups would have reduced statistical power. However, cases where individuals received only an initial assessment should not cancel any real effects among individuals who received treatment. Similarly, it is possible that the 2-year interval between measurements could have obscured temporary improvements that had occurred before the 3-month period assessed at each time point.
Findings from some studies suggest that evidence-based psychotherapies have smaller effects when implemented as part of usual care, compared with the effects seen in efficacy studies of these interventions in highly controlled settings. Ng and Weisz (
28) ascribed these observations to potential mismatches between evidence-based psychotherapies and usual care. These mismatches may arise because patients in usual care are a more heterogeneous group with more comorbid conditions; moreover, their conditions follow a less predictable course, resulting in shifting treatment needs during therapy. Although many evidence-based approaches provide flexibility, they usually lack approaches to manage comorbid conditions, crises, and other treatment challenges. This lack could explain why evidence-based approaches are frequently not implemented in usual care and may not be as well suited for many children seen in this setting. Furthermore, logistic barriers, such as insufficient time and training of providers, could be important obstacles to implementing new treatments (
29).
We found that the number of psychiatric symptoms increased more among preschoolers who received services than among those who did not. Before it may be concluded that service provision to this age group does more harm than good, several alternative explanations should be considered. First, we could not carry out a comprehensive propensity adjustment for children receiving treatment at ages 0–4. As indicated by previous research, factors included in the propensity score at later ages predict increased referrals to treatment during early childhood (
5) and worsening of symptoms (
30). Not including these factors in the propensity score for T1 could have produced bias suggesting a detrimental effect of service provision. However, we adjusted for the propensity to use services between age 5 and 6 and still found that service use predicted increased symptoms. Second, some time-varying factors might be responsible for worsening symptoms and the initiation of services that were not included in our propensity score. Third, behavioral problems are more strongly associated with referrals than are emotional problems (
5,
18,
20). Addressing such overt behavioral symptoms may leave co-occurring emotional problems untreated, and these emotional problems may persist or worsen over time. Fourth, children receiving services at ages 0–4 could be in the initial phase of more chronic conditions, implying that the worsening of symptoms would have been more severe without intervention. Finally, receiving services may moderate the negative effects of adverse life events (e.g., parental divorce or bullying) and thus potentially reduce the negative impact of such events among vulnerable children. In any event, the potential negative effects of service use observed in this study require validation in future studies.
Importantly, these results may not generalize to health care systems outside of Norway. However, Norway consistently ranks as one of the wealthiest countries in the world per capita, with a well-developed public health care system (
31). We have no reason to believe that Norwegian services provide particularly poor care compared with services in other countries.
Conclusions
In the context of the uncertainty of results obtained from observational research, the effect of usual care on young children may be small or even absent, a possibility that should be investigated in a variety of countries. There is a need to develop and implement evidence-based approaches to treat children with mental health problems in routine clinical practice.