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Abstract

Validated, multicomponent treatments designed to address symptoms and functioning of individuals at clinical high risk for psychosis are currently lacking. The authors report findings of a study with such individuals participating in step-based care—a program designed to provide low-intensity, non–psychosis-specific interventions and advancement to higher-intensity, psychosis-specific interventions only if an individual is not meeting criteria for a clinical response. Among individuals with symptomatic or functional concerns at enrollment, 67% met criteria for a symptomatic response (median time to response=11.1 weeks), and 64% met criteria for a functional response (median time to response=8.9 weeks).

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Information & Authors

Information

Published In

Go to Psychiatric Services
Go to Psychiatric Services
Psychiatric Services
Pages: 496 - 499
PubMed: 38088038

History

Received: 18 April 2023
Revision received: 26 October 2023
Accepted: 13 November 2023
Published online: 13 December 2023
Published in print: May 01, 2024

Keywords

  1. Psychoses
  2. Stepped care
  3. Clinical high risk for psychosis
  4. Outcome and clinical measurement

Authors

Affiliations

Sarah A. Hamilton, M.D. [email protected]
Department of Psychiatry and Behavioral Health (all authors) and Department of Psychology (Moe, Breitborde), Ohio State University, Columbus.
Heather M. Wastler, Ph.D.
Department of Psychiatry and Behavioral Health (all authors) and Department of Psychology (Moe, Breitborde), Ohio State University, Columbus.
Aubrey M. Moe, Ph.D.
Department of Psychiatry and Behavioral Health (all authors) and Department of Psychology (Moe, Breitborde), Ohio State University, Columbus.
Henry R. Cowan, Ph.D.
Department of Psychiatry and Behavioral Health (all authors) and Department of Psychology (Moe, Breitborde), Ohio State University, Columbus.
Nancy B. Lundin, Ph.D.
Department of Psychiatry and Behavioral Health (all authors) and Department of Psychology (Moe, Breitborde), Ohio State University, Columbus.
Hossam H. Guirgis, M.D.
Department of Psychiatry and Behavioral Health (all authors) and Department of Psychology (Moe, Breitborde), Ohio State University, Columbus.
Craig J. Parris, A.P.R.N.-C.N.P.
Department of Psychiatry and Behavioral Health (all authors) and Department of Psychology (Moe, Breitborde), Ohio State University, Columbus.
Walter H. Stearns, M.D.
Department of Psychiatry and Behavioral Health (all authors) and Department of Psychology (Moe, Breitborde), Ohio State University, Columbus.
Margaret E. Manges, M.Ed.
Department of Psychiatry and Behavioral Health (all authors) and Department of Psychology (Moe, Breitborde), Ohio State University, Columbus.
Anne C. Holmes, Ph.D.
Department of Psychiatry and Behavioral Health (all authors) and Department of Psychology (Moe, Breitborde), Ohio State University, Columbus.
Alexandra M. Blouin, B.S.
Department of Psychiatry and Behavioral Health (all authors) and Department of Psychology (Moe, Breitborde), Ohio State University, Columbus.
Nicholas J. K. Breitborde, Ph.D.
Department of Psychiatry and Behavioral Health (all authors) and Department of Psychology (Moe, Breitborde), Ohio State University, Columbus.

Notes

Send correspondence to Dr. Hamilton ([email protected]). Marcela Horvitz-Lennon, M.D., and Kenneth Minkoff, M.D., are editors of this column.
The study data were presented at the Society for Research in Psychopathology conference, Philadelphia, September 9, 2022.

Competing Interests

Dr. Guirgis reports providing consultation to Karuna Therapeutics. The other authors report no financial relationships with commercial interests.

Funding Information

This work was supported by the Substance Abuse and Mental Health Services Administration (awards SM081154-01, SM081154-01M001, and SM086173-01) and through cost-matching funds provided by the Alcohol, Drug and Mental Health Board of Franklin County, Ohio, and Ohio State University.

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