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Clinical & Research News
Published Online: 1 July 2011

Antipsychotics and Dementia Patients: Key Study Findings

Publication: Psychiatric News
Volume 46, Number 13
https://doi.org/10.1176/pn.46.13.psychnews_46_13_20_2
Alzheimer's patients taking antipsychotics showed steady, significant declines over time in most cognitive areas, including in scores on the Mini-Mental State Examination (MMSE) and the cognitive subscale of the Alzheimer's Disease Assessment Scale.
Cognitive function declined more in patients receiving antipsychotics than in those given placebo on multiple cognitive measures, including the MMSE, the cognitive subscale of the Brief Psychiatric Rating Scale, and a cognitive summary score summarizing change on 18 cognitive tests.
Physicians prescribing antipsychotic medications for Alzheimer's patients with aggression and delusions should consider discontinuing the drugs if patients do not respond.

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Psychiatric News
Volume 46 • Number 13 • July 1, 2011
Pages: 20

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Published online: 1 July 2011
Published in print: July 1, 2011

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